Gene Page - CG Number : CG1058

Gene Summary - CG1058:

CG1058: The gene ripped pocket is referred to in FlyBase by the symbol Dmel\rpk (CG1058, FBgn0022981). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-gated sodium channel activity; sodium channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: sodium ion transport. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Na+ channel, amiloride-sensitive; Na+ channel, amiloride-sensitive, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG1058 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG1058:

CG1058 is perturbed in following parameters in primary screen: Fmph1 Tint2 Tint3 Tmph1
CG1058 is perturbed in following parameters in classification assay (fluid): LP_Fint2+ LP_Fint3+ LP_Fmph1+ NuCirc+(fld) NuSize-(fld) SP_Fmph2- SP_Fmph3- SP_Fnum-
CG1058 is not tested in classification assay (transferrin).

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG1058.

Cell Count:

CG_Number	Category	R1	R2	R3
CG1058	Primary screen	381	208	288

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG1058:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

Fluid:

CG_Number	Slide No.	ttest P-value	Ratio 1	Ratio 2	Ratio 3
CG1058	Slide19C	0.062	1.139	1.153	1.345
CG1058	Slide19O	0.349	1.618	1.036	1.046
CG1058	Slide19P	0.102	1.100	1.093	1.277

C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG1058 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
sodium ion transport	GO:0006814	inferred from electronic annotation with InterPro:IPR001873, InterPro:IPR020903

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
membrane	GO:0016020	inferred from electronic annotation with InterPro:IPR001873, InterPro:IPR020903

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
sodium channel activity	GO:0005272	inferred from sequence or structural similarity sodium channel activity

Other annotations

Database	Link
FlyBase	Click here to see CG1058 in FlyBase
FLIGHT	Click here to see CG1058 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG1058 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG1058
Entrez Gene	Entrez Gene page for CG1058
Uniprot	Uniprot page for CG1058

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)