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Gene Page - CG Number : CG10580
Gene Summary - CG10580:

CG10580: The gene fringe is referred to in FlyBase by the symbol Dmel\fng (CG10580, FBgn0011591). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: UDP-glycosyltransferase activity; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity; acetylglucosaminyltransferase activity. There is experimental evidence for 13 unique biological process terms, many of which group under: system development; post-embryonic organ morphogenesis; regionalization; biological regulation; sensory organ development; appendage development; dorsal/ventral pattern formation, imaginal disc; instar larval or pupal morphogenesis; macromolecule modification; hexose metabolic process; multicellular organism reproduction. 68 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: organ system subdivision; adult segment; organ system; thoracic segment; late extended germ band embryo; ectoderm derivative; external compound sense organ; non-connected developing system; extended germ band embryo; portion of tissue. It has one annotated transcript and one annotated polypeptide. Protein features are: Fringe; Fringe-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages.

Gene summary for CG10580 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10580:CG10580 is perturbed in following parameters in primary screen: Fint1 Fint2 Fint3 Fmph1 Fmph2 Tclc
CG10580 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) CellSize-(fld) LP_Fclc+ LP_Fclc- LP_Fint2- LP_Fint3- LP_Fmph1- LP_Fmph2+ LP_Fmph3- LP_Fnum- NuSize-(fld) NuSize-(fld) Okt+(fld) Okt+(fld) Rto1+ Rto1+ Rto2+ Rto2+ Rto3+ Rto3+ SP_Fclc+ SP_Fclc- SP_Fint1+ SP_Fint1+ SP_Fint2+ SP_Fint3+ SP_Fint4- SP_Fmph1+ SP_Fmph1- SP_Fmph2+ SP_Fmph2- SP_Fmph3+ SP_Fmph3- SP_Fnum+ SP_Fnum-
CG10580 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10580.
Cell Count:
CG_NumberCategoryR1R2R3
CG10580Primary screen843107359
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10580:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191267-0.5399263-0.066985458-0.0065044620.2413527761.3192361930.9775885680.4369445471.2183869671.447557073-0.58174953-0.1412360020.479886198-0.376179892-0.2620694480.3198459131.2995584970.266174968-0.1132659790.1007665581.733993321-0.09493872.6433073223.020596941
1924914.1746615912.1788892612.593861214.5608479654.96747497516.9213431211.4840529819.558480578.2952514016.8717013611.1993548621.766103937-0.883624955-0.6695838294.8462149189.42185531718.803039919.16197961220.252956296.7086258182.8496719370.1874947272.14786236
1931994.6665622625.9444025115.3974189362.4082954752.5115454483.8366500297.0340720662.5925275282.0630202091.1502673941.548492635-0.2162347940.7276619590.8369483941.565753970.1136807140.4133096920.275277870.5740880863.128179319-0.283953108-0.48692934-0.406112714
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10580Slide16C0.1770.9630.8480.820
CG10580Slide16O0.0011.3581.2711.269
CG10580Slide16P0.0001.9241.7612.035
CG10580Slide4C0.0070.6630.7060.816
CG10580Slide4O0.0101.3561.4181.591
CG10580Slide4P0.6911.0260.9801.048
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10580 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
imaginal disc-derived wing margin morphogenesisGO:0008587inferred from mutant phenotype
imaginal disc-derived wing morphogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Golgi apparatusGO:0005794inferred from direct assay
Golgi apparatus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
UDP-glycosyltransferase activityGO:0008194inferred from direct assay
acetylglucosaminyltransferase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10580 in FlyBase
FLIGHTClick here to see CG10580 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10580 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10580
Entrez GeneEntrez Gene page for CG10580
UniprotUniprot page for CG10580

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)