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Gene Page - CG Number : CG10586
Gene Summary - CG10586:

CG10586: The gene Seminase is referred to in FlyBase by the symbol Dmel\Sems (CG10586, FBgn0037036). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: zymogen activation; negative regulation of female receptivity, post-mating; multicellular organism reproduction; sperm storage. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S1/S6, chymotrypsin/Hap; Peptidase S1/S6, chymotrypsin/Hap, active site; Peptidase S1A, chymotrypsin-type; Peptidase cysteine/serine, trypsin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages.

Gene summary for CG10586 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10586:CG10586 is not perturbed in primary screen.
CG10586 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10586.
Cell Count:
CG_NumberCategoryR1R2R3
CG10586Primary screen554623387
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10586:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191272-0.1561405250.337649241-0.073486151-0.697004465-0.0237990710.3875363310.1010733320.4832225110.4442934170.995103129-0.081491972-0.6758970351.2299296951.54738640.206471224-0.6866824690.282482196-0.0552748690.8601141740.125490495-0.7616261472.5832437512.064429752
19214-0.1595224520.1782072760.39723511-0.5281039490.459347111.3881374432.2581007211.3226412011.256953431-0.1485323010.3697194540.4568178330.1451064630.120759314-0.2637771590.4492173720.5332037110.9917347240.3576399881.6871792620.1764502250.9458420160.653136186
1931640.817207582-0.391575923-0.1701798580.5196133380.9374757791.0866927841.936189821.1815456371.4185767270.445842740.2457208080.0578924291.3257324821.7761053442.1654654020.0246381830.5369124960.2518366980.6000375641.3511698680.07196171-0.64153476-0.058643482
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10586 is not tested in classification assay
Integrated Annotations for CG10586 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508non-traceable author statement
zymogen activation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
extracellular spaceGO:0005615inferred from direct assay
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
endopeptidase activityGO:0004175inferred from sequence or structural similarity with EMBL:U66061
serine-type endopeptidase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10586 in FlyBase
FLIGHTClick here to see CG10586 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10586 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10586
Entrez GeneEntrez Gene page for CG10586
UniprotUniprot page for CG10586

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)