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Gene Page - CG Number : CG10602
Gene Summary - CG10602:

CG10602: This gene is referred to in FlyBase by the symbol Dmel\CG10602 (FBgn0032721). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: leukotriene-A4 hydrolase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: proteolysis; translation; leukotriene biosynthetic process. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Armadillo-type fold; Leukotriene A4 hydrolase; Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase; Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal; Peptidase M1, membrane alanine aminopeptidase, N-terminal; Ribosomal protein L13 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult female stages.

Gene summary for CG10602 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10602:CG10602 is perturbed in following parameters in primary screen: Fint2
CG10602 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fclc- LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4- NuSize-(fld) Okt+(fld) SP_Fint2+ SP_Fint3+ SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10602 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10602.
Cell Count:
CG_NumberCategoryR1R2R3
CG10602Primary screen6939311
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10602:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
1912820.8871500474.5059230261.527265623-0.3414542210.4941696330.8598659591.1429042282.017968310.3165138080.3496403980.665415416-0.189597166-1.2626582430.3522369090.7576988040.282367862-1.3536129990.36932547-0.4100550780.196388891-0.3228380190.173353461.509305139
1924-0.601931411-0.597965859-0.076999485-0.385948424-2.976639558-1.420093493-1.967834296-2.837565639-1.984312197-0.302168735-1.906203262-1.692548093-0.7564282921.148278408-1.322055379-1.7785187810.40024393-0.1268951211.224964636-1.398567742-1.502227689-0.919966193-1.781646016
1931544.7569355983.6490275591.5078617720.1661100830.3841601371.0536991132.9439209690.6552678480.810662943-0.716394334-0.026998630.0215217770.7181063210.489664517-0.643722264-0.908831163-1.090271733-0.643593919-1.0438138910.8436918690.433332976-0.205947339-0.127524322
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10602Slide19C0.0011.3851.4971.376
CG10602Slide19O0.0071.4571.7371.657
CG10602Slide19P0.0391.2471.2001.127
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10602 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
translationGO:0006412inferred from electronic annotation with InterPro:IPR023564
leukotriene biosynthetic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
ribosomeGO:0005840inferred from electronic annotation with InterPro:IPR023564
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
leukotriene-A4 hydrolase activityGO:0004463inferred from sequence or structural similarity with UniProtKB:P24527
structural constituent of ribosome
Other annotations
DatabaseLink
FlyBaseClick here to see CG10602 in FlyBase
FLIGHTClick here to see CG10602 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10602 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10602
Entrez GeneEntrez Gene page for CG10602
UniprotUniprot page for CG10602

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)