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Gene Page - CG Number : CG1063
Gene Summary - CG1063:

CG1063: The gene Inositol 1,4,5,-tris-phosphate receptor is referred to in FlyBase by the symbol Dmel\Itp-r83A (CG1063, FBgn0010051). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. There is experimental evidence that it is involved in the biological process: larval feeding behavior; cellular calcium ion homeostasis; stabilization of membrane potential; response to oxidative stress; nuclear division; flight behavior; molting cycle, chitin-based cuticle; mushroom body development; release of sequestered calcium ion into cytosol; sensory perception of taste. 42 alleles are reported. The phenotypes of these alleles are annotated with: dorsal medial muscle; mushroom body; wing margin; mesothoracic tergum; wing; antennal lobe; indirect flight muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Inositol 1,4,5-trisphosphate-binding protein receptor; Inositol 1,4,5-trisphosphate/ryanodine receptor; Intracellular calcium-release channel; Ion transport domain; MIR motif; RyR/IP3R Homology associated domain; Ryanodine receptor-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages.

Gene summary for CG1063 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1063:CG1063 is perturbed in following parameters in primary screen: Fmph2
CG1063 is perturbed in following parameters in classification assay (fluid): LP_Fnum- Okt+(fld)
CG1063 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1063.
Cell Count:
CG_NumberCategoryR1R2R3
CG1063Primary screen234648185
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1063:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1063Slide8C0.6241.0610.9480.880
CG1063Slide8O0.0671.1861.2031.053
CG1063Slide8P0.8991.1361.0470.857
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG1063 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
flight behaviorGO:0007629inferred from mutant phenotype
molting cycle, chitin-based cuticle
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
endoplasmic reticulum membraneGO:0005789non-traceable author statement
endoplasmic reticulum
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityGO:0005220inferred from direct assay
calcium channel activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1063 in FlyBase
FLIGHTClick here to see CG1063 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1063 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1063
Entrez GeneEntrez Gene page for CG1063
UniprotUniprot page for CG1063

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)