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Gene Page - CG Number : CG10637
Gene Summary - CG10637:

CG10637: The gene Numb-associated kinase is referred to in FlyBase by the symbol Dmel\Nak (CG10637, FBgn0015772). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; AP-2 adaptor complex binding. There is experimental evidence that it is involved in the biological process: regulation of clathrin-mediated endocytosis; dendrite morphogenesis; asymmetric cell division. 18 alleles are reported. The phenotypes of these alleles are annotated with: head sensillum; adult mesothoracic sensillum; wing sensillum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG10637 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10637:CG10637 is not perturbed in primary screen.
CG10637 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10637.
Cell Count:
CG_NumberCategoryR1R2R3
CG10637Primary screen5656196
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10637:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
191300-0.6341932950.4550679441.7195538530.0326008740.891555629-0.129820891-1.057418061-0.36980709-1.8542894270.117033535-0.0275867071.184989824-0.91533604-0.696362729-0.2490830880.308594999-1.992334289-0.274160799-0.363023222-2.319989258-0.4583202050.7720581390.096448081
19216-0.6461656410.290783105-1.254485953-0.588827457-3.028284298-2.171006705-2.574131403-3.79424034-4.207435093-1.890982774-1.983757651-1.404624718-2.215522044-2.239480907-0.799690209-3.195494248-3.275121863-2.381974173-3.239922869-3.7605810160.061741902-0.943296802-1.79471232
193166-0.786927664-0.4181676030.013157868-0.608745388-0.706808732-0.5521630750.059912905-0.552594588-0.823396225-1.233194549-0.443394282-0.2544627810.459048125-0.759365453-0.098720888-1.177117995-1.391641903-1.347908593-1.39910829-1.325240365-0.817960682-0.890979458-0.262511045
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10637 is not tested in classification assay
Integrated Annotations for CG10637 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dendrite morphogenesisGO:0048813inferred from mutant phenotype
regulation of clathrin-mediated endocytosis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
dendriteGO:0030425inferred from direct assay
neuronal cell body
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
AP-2 adaptor complex bindingGO:0035612inferred from direct assay
protein serine/threonine kinase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10637 in FlyBase
FLIGHTClick here to see CG10637 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10637 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10637
Entrez GeneEntrez Gene page for CG10637
UniprotUniprot page for CG10637

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)