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Gene Page - CG Number : CG1065
Gene Summary - CG1065:

CG1065: The gene Succinyl coenzyme A synthetase α subunit is referred to in FlyBase by the symbol Dmel\Scsα (CG1065, FBgn0004888). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: succinate-CoA ligase (GDP-forming) activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ATP-citrate lyase/succinyl-CoA ligase; ATP-citrate lyase/succinyl-CoA ligase, active site; CoA-binding; NAD(P)-binding domain; Succinyl-CoA ligase, alpha subunit; Succinyl-CoA synthetase-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG1065 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1065:CG1065 is perturbed in following parameters in primary screen: Rto2 Tclc Tmph1
CG1065 is not tested in classification assay (fluid).
CG1065 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fclc- Fint4- Fmph1- Fmph2- Fmph3- Fnum- Rto1-(tfr) Rto2+(tfr) Rto3+(tfr) Tclc- Tint4- Tmph1- Tmph2- Tmph3- Tnum-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1065.
Cell Count:
CG_NumberCategoryR1R2R3
CG1065Primary screen25311136
CG1065Secondary assay108312961355
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1065:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1065Slide1F0.2040.8720.9400.966
CG1065Slide1O0.6630.9831.0291.025
CG1065Slide1T0.0070.8030.7530.856
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1065 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
tricarboxylic acid cycleGO:0006099non-traceable author statement
tricarboxylic acid cycle
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
succinate-CoA ligase complex (GDP-forming)GO:0045244inferred from sequence or structural similarity with EMBL:AF104921; protein_id:AAD17940
succinate-CoA ligase complex (GDP-forming)
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
succinate-CoA ligase (GDP-forming) activityGO:0004776non-traceable author statement
succinate-CoA ligase (GDP-forming) activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1065 in FlyBase
FLIGHTClick here to see CG1065 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1065 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1065
Entrez GeneEntrez Gene page for CG1065
UniprotUniprot page for CG1065

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)