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Gene Page - CG Number : CG10653
Gene Summary - CG10653:

CG10653: The gene hook is referred to in FlyBase by the symbol Dmel\hk (CG10653, FBgn0001202). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: microtubule binding. There is experimental evidence that it is involved in the biological process: cytoskeleton-dependent intracellular transport; endocytosis; determination of adult lifespan; phagocytosis, engulfment. 30 alleles are reported. The phenotypes of these alleles are annotated with: glial cell; eye disc; macrochaeta; lysosome; multivesicular body; endosome; ommatidium; synapse. It has one annotated transcript and one annotated polypeptide. Protein features are: HOOK. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.

Gene summary for CG10653 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10653:CG10653 is not perturbed in primary screen.
CG10653 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10653.
Cell Count:
CG_NumberCategoryR1R2R3
CG10653Primary screen6108493
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10653:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20190.021834935-0.411745175-0.131836848-0.1570276251.218939909-1.651129740.027931451-1.931667795-1.6087622841.032300548-0.841953634-0.607068436-0.83882022-0.325100845-0.2354503260.414569474-1.990496968-1.477679147-0.607650584-0.9171350530.630132952-0.188280522-0.512315365
202157-0.587584550.140066713-1.057071424-1.465351657-2.950922926-2.033622722-1.921474785-1.887773048-2.951662607-0.474931447-2.332995807-0.491581028-2.138156957-1.1938010660.197243371-2.711428697-1.504825635-1.031932815-1.742674162-2.24922321-1.013753611-1.410510772-1.989792807
203127-0.63943488-0.0034158910.209314428-0.5972051691.2878550161.7713155643.0052202361.8155961681.9091278750.7216560070.479037716-0.5273981711.0404383910.870721151.3667559680.6065901070.6559653290.4583307091.1477352252.1202153340.108878322-0.544167021-0.448424213
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10653 is not tested in classification assay
Integrated Annotations for CG10653 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
determination of adult lifespanGO:0008340inferred from mutant phenotype
endocytosis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
endosomeGO:0005768inferred from direct assay
synapse
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
microtubule bindingGO:0008017inferred from direct assay
Other annotations
DatabaseLink
FlyBaseClick here to see CG10653 in FlyBase
FLIGHTClick here to see CG10653 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10653 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10653
Entrez GeneEntrez Gene page for CG10653
UniprotUniprot page for CG10653

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)