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Gene Page - CG Number : CG10667
Gene Summary - CG10667:

CG10667: The gene Origin recognition complex subunit 1 is referred to in FlyBase by the symbol Dmel\Orc1 (CG10667, FBgn0022772). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: DNA amplification; DNA replication initiation; cell proliferation; neurogenesis. 17 alleles are reported. The phenotypes of these alleles are annotated with: chorion; eye; trichogen cell; interommatidial bristle; egg; mesothoracic tergum; ommatidium; dorsal appendage; stage S10B oocyte; morphogenetic furrow. It has one annotated transcript and one annotated polypeptide. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, core; Bromo adjacent homology (BAH) domain; CDC6, C-terminal domain; Origin recognition complex, subunit 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10667 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10667:CG10667 is not perturbed in primary screen.
CG10667 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10667.
Cell Count:
CG_NumberCategoryR1R2R3
CG10667Primary screen80389396
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10667:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20115-0.3409036591.0772094620.2437980090.0367601140.3350605471.1749368312.3364182611.5686406232.022940912-0.5638430410.8048709760.349532767-0.096984818-0.3824209360.2629691870.5467964230.387826221.3709807730.8043113682.6418712591.3558257493.9870377722.853662596
2021514.2893092163.2688822350.986586640.759036803-1.5897033361.594355062.102779814-0.2888643590.8291197822.640307361-0.105718782-0.828596828-0.153978153-0.7952783845.7537088660.5629501234.062182672.2274311745.4408567190.598404344-0.3000255350.40704151-0.290037446
2031210.524806096-0.302446240.0671017271.0800880690.2505048260.483551120.222199270.3977690480.748895005-0.0709608310.39437129-0.721191209-0.371519055-0.1132988940.7579663850.2602743870.2688404290.0243512720.5678841290.3163561550.4845719680.791369410.755977284
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10667 is not tested in classification assay
Integrated Annotations for CG10667 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
DNA-dependent DNA replicationGO:0006261inferred from sequence or structural similarity with EMBL:AJ003133; protein_id:CAA05890
DNA-dependent DNA replication initiation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nuclear origin of replication recognition complexGO:0005664inferred from sequence or structural similarity with EMBL:AJ003133; protein_id:CAA05890
nuclear origin of replication recognition complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677non-traceable author statement
ATP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10667 in FlyBase
FLIGHTClick here to see CG10667 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10667 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10667
Entrez GeneEntrez Gene page for CG10667
UniprotUniprot page for CG10667

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)