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Gene Page - CG Number : CG10688
Gene Summary - CG10688:

CG10688: This gene is referred to in FlyBase by the symbol Dmel\CG10688 (FBgn0036300). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: phosphomannomutase activity. There is experimental evidence that it is involved in the biological process: cellular response to hypoxia. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Eukaryotic phosphomannomutase; HAD-like domain; HAD-superfamily hydrolase, subfamily IIB. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG10688 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10688:CG10688 is not perturbed in primary screen.
CG10688 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint3- Rto3- SP_Fint3- SP_Fint4- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG10688 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10688.
Cell Count:
CG_NumberCategoryR1R2R3
CG10688Primary screen637382395
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10688:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20126-0.420444124-0.328836737-0.746178015-0.3020607970.2002484910.7615186810.3255537750.9822124560.4570887440.874803669-0.1865962050.773168546-0.5464816340.3687099461.5713328630.333983923-1.7870503940.294032891-2.7034441420.2944232510.4925230252.8391629192.666222658
202170-0.296445793-0.600150573-0.363819033-0.482077554-0.101764590.1185455070.948788525-0.1393635590.7110217250.4306681171.0288080950.2669618960.8119586920.3464143250.17983609-0.0437514920.7941710771.6197238820.468387140.603039707-0.787660727-0.470540731-0.050452624
203140-0.757440793-0.247406762-0.485268935-0.2810179540.7714519391.4246528341.5699914421.1979895861.5618415223.0837242571.5814506030.8891794641.9234608652.3747016831.4079490631.1593495081.2210339161.8063259381.2096891571.597667207-0.017376998-0.559916268-0.477633112
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10688Slide17C0.0890.8930.7760.624
CG10688Slide17O0.4940.9320.9651.007
CG10688Slide17P0.0720.8670.6640.491
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10688 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
GDP-mannose biosynthetic processGO:0009298non-traceable author statement
cellular response to hypoxia
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737non-traceable author statement
cytoplasm
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
phosphomannomutase activityGO:0004615inferred from sequence or structural similarity with UniProtKB:P07283
phosphomannomutase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10688 in FlyBase
FLIGHTClick here to see CG10688 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10688 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10688
Entrez GeneEntrez Gene page for CG10688
UniprotUniprot page for CG10688

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)