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Gene Page - CG Number : CG10689
Gene Summary - CG10689:

CG10689: The gene lethal (2) 37Cb is referred to in FlyBase by the symbol Dmel\l(2)37Cb (CG10689, FBgn0086444). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent RNA helicase activity; RNA helicase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 39 alleles are reported. The phenotype of these alleles is annotated with: adult thorax. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Domain of unknown function DUF1605; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; Helicase-associated domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10689 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10689:CG10689 is not perturbed in primary screen.
CG10689 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10689.
Cell Count:
CG_NumberCategoryR1R2R3
CG10689Primary screen480420241
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10689:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20127-0.3149696822.1020080631.10126511-0.400732115-0.7434349380.201655020.7745962231.0131213150.3104493221.2496653961.263356546-0.5214078820.275831585-0.4371851952.535522533-0.611471389-1.8159180881.13379473-2.7231181441.4778576920.747265388-0.175431245-0.624625666
2021692.197352916-0.1055151890.403523876-0.6705305970.1175871270.6869226150.7892753690.4353748080.6250306220.0641163330.1765781690.1257691350.9658382010.292286908-0.3485126660.0395823720.42128285-0.118867338-0.449624710.7167799180.08407975-0.579301663-0.507057118
203139-0.088132121-0.161480073-0.598662573-0.717051289-0.409825942-0.07709981-0.421235463-0.230195127-0.680027711.016155831-0.2425731921.4679075710.6942077650.9756482540.129995538-0.325328476-0.520753648-0.553197483-0.55062017-1.0470614480.440054109-0.457371657-0.801000737
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10689 is not tested in classification assay
Integrated Annotations for CG10689 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
nuclear mRNA splicing, via spliceosomeGO:0000398inferred from sequence or structural similarity with SGD_LOCUS:PRP22; SGD:S0000815
nuclear mRNA splicing, via spliceosome
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
spliceosomal complexGO:0005681inferred from sequence or structural similarity with SGD_LOCUS:PRP22; SGD:S0000815
spliceosomal complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
ATP-dependent RNA helicase activityGO:0004004inferred from sequence or structural similarity with SGD_LOCUS:PRP2; SGD:S0000815
RNA helicase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10689 in FlyBase
FLIGHTClick here to see CG10689 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10689 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10689
Entrez GeneEntrez Gene page for CG10689
UniprotUniprot page for CG10689

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)