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Gene Page - CG Number : CG10692
Gene Summary - CG10692:

CG10692: The gene Methyltransferase 2 is referred to in FlyBase by the symbol Dmel\Mt2 (CG10692, FBgn0028707). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tRNA methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity. There is experimental evidence that it is involved in the biological process: gene silencing; determination of adult lifespan; tRNA methylation; response to oxidative stress; DNA hypermethylation; telomere maintenance; DNA methylation involved in embryo development; response to heat; DNA methylation. 16 alleles are reported. The phenotype of these alleles is annotated with: eye disc posterior to the morphogenetic furrow. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: C-5 cytosine methyltransferase; DNA methylase, C-5 cytosine-specific, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10692 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10692:CG10692 is not perturbed in primary screen.
CG10692 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10692.
Cell Count:
CG_NumberCategoryR1R2R3
CG10692Primary screen625645367
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10692:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201290.2288030123.2440058472.2430955190.010440547-0.5425544550.8658191553.2005993031.1366996491.517749156-0.455720515-0.4176637441.218968911.347559122-0.0787120150.469324503-0.439204968-0.345681563-0.829559237-1.4246291533.0013699610.2425596420.6565375331.34370335
2021670.279380491-0.1520290670.199131731-0.20316140.6570679840.7479043241.2443873880.6574175351.3665372920.6496375610.791249759-0.3138559211.0406082860.7565365520.4410595260.2377975131.1471442971.1300852280.9103765991.463315827-0.028765153-0.248076014-0.233247318
203137-0.856269859-0.460959139-0.309961817-1.1355014521.0002987570.8610631251.0364260340.9557258941.161447941.4514602591.748563048-0.1230908190.4670002630.7835863181.0279889340.7144670230.9265277210.7434484271.1652214661.1284924691.1726712080.7975089740.043458229
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10692 is not tested in classification assay
Integrated Annotations for CG10692 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
DNA methylationGO:0006306inferred from sequence or structural similarity with MGD:Dnmt2; MGI:MGI:1274787
DNA methylation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nuclear chromatinGO:0000790colocalizes_with non-traceable author statement
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA (cytosine-5-)-methyltransferase activityGO:0003886inferred from sequence or structural similarity with EMBL:AF012129
DNA (cytosine-5-)-methyltransferase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10692 in FlyBase
FLIGHTClick here to see CG10692 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10692 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10692
Entrez GeneEntrez Gene page for CG10692
UniprotUniprot page for CG10692

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)