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Gene Page - CG Number : CG10697
Gene Summary - CG10697:

CG10697: The gene Dopa decarboxylase is referred to in FlyBase by the symbol Dmel\Ddc (CG10697, FBgn0000422). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: aromatic-L-amino-acid decarboxylase activity. There is experimental evidence for 11 unique biological process terms, many of which group under: single-organism behavior; multicellular organismal process; anatomical structure development; organonitrogen compound metabolic process; memory; oxoacid metabolic process; learning or memory; organic acid metabolic process; serotonin biosynthetic process from tryptophan; response to stress; growth; locomotion; response to temperature stimulus; biological regulation. 145 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; adult segment; organ system subdivision; adult mesothoracic segment; cuticle; sensillum; sense organ; thoracic segment; wing hair; eo support cell; adult cuticle. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Aromatic-L-amino-acid decarboxylase; Pyridoxal phosphate-dependent decarboxylase; Pyridoxal phosphate-dependent transferase, major domain; Pyridoxal phosphate-dependent transferase, major region, subdomain 1; Pyridoxal phosphate-dependent transferase, major region, subdomain 2; Pyridoxal-phosphate binding site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late larval stages.

Gene summary for CG10697 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10697:CG10697 is not perturbed in primary screen.
CG10697 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10697.
Cell Count:
CG_NumberCategoryR1R2R3
CG10697Primary screen61513480
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10697:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20133-0.9299090543.4433391953.1882856340.7173050881.1497580820.114199703-0.006345616-0.067415892-0.333455555-0.013227364-0.8213638460.368218588-0.1291403450.1869202020.873472087-0.68725581-0.131072502-1.061887445-2.3427882370.7728323180.1200068760.3429892431.089497852
202193-0.9311098560.937014985-0.4219082760.5547363-1.303159792-1.754566837-1.476759443-1.25902439-0.839995056-0.038985038-0.2890643970.0806985240.1604906630.9470138260.370124283-0.980374450.5485678410.2839976610.368296781-0.400121039-0.3737677770.671669351-0.31838262
2031033.2449901990.8279184240.903066267-0.914790974-4.340969979-5.513348071-5.882610114-5.223157077-3.89541662-0.960397626-0.594957475-0.452678663-2.246256229-0.644092179-0.28380136-2.17089469-2.115563903-1.397174383-2.456758361-4.921920609-0.259163605-0.195732856-0.120778926
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10697 is not tested in classification assay
Integrated Annotations for CG10697 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dopamine biosynthetic process from tyrosineGO:0006585inferred from mutant phenotype
serotonin biosynthetic process from tryptophan
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
aromatic-L-amino-acid decarboxylase activityGO:0004058inferred from mutant phenotype
aromatic-L-amino-acid decarboxylase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10697 in FlyBase
FLIGHTClick here to see CG10697 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10697 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10697
Entrez GeneEntrez Gene page for CG10697
UniprotUniprot page for CG10697

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)