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Gene Page - CG Number : CG10701
Gene Summary - CG10701:

CG10701: The gene Moesin is referred to in FlyBase by the symbol Dmel\Moe (CG10701, FBgn0011661). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; phosphatidylinositol-4,5-bisphosphate binding. There is experimental evidence that it is involved in the biological process: determination of left/right symmetry; olfactory behavior; oocyte anterior/posterior axis specification; actin cytoskeleton organization; establishment or maintenance of epithelial cell apical/basal polarity; establishment or maintenance of polarity of larval imaginal disc epithelium; rhabdomere membrane biogenesis; rhabdomere development; regulation of actin cytoskeleton organization; regulation of membrane potential in photoreceptor cell. 104 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: adult segment; organ system subdivision; organ system; thoracic segment; external compound sense organ; non-connected developing system; imaginal precursor; dorsal trunk primordium; organelle; embryonic hindgut; embryonic foregut. It has 13 annotated transcripts and 13 annotated polypeptides. Protein features are: Band 4.1 domain; Band 4.1 family; Ezrin/radixin/moesin; Ezrin/radixin/moesin family; Ezrin/radixin/moesin, C-terminal; FERM central domain; FERM conserved site; FERM domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM/acyl-CoA-binding protein, 3-helical bundle; Moesin; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in adult female stages.

Gene summary for CG10701 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10701:CG10701 is not perturbed in primary screen.
CG10701 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10701.
Cell Count:
CG_NumberCategoryR1R2R3
CG10701Primary screen7541149
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10701:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20138-0.3341626287.3281586866.1269309230.5980157610.66556621.0122137873.3990353961.4544974371.998029327-0.6852193220.4755911010.0791048061.0203774410.962149047-0.3442639330.000109553-1.659423911-0.396938774-2.9953010641.861284361-0.2187810383.5305792423.907266231
202188-0.514672065-1.629223629-0.407309139-2.376944462-2.949855268-1.479367426-1.866343053-1.927445707-4.094798025-1.326860682-1.655351714-0.468431221-1.708841781-1.086744849-0.49393397-3.328479707-2.210650093-2.437897143-2.678459885-4.133966319-0.655497984-3.533772606-4.303791552
203981.3908424091.1544979270.9470787812.5080232-1.670323757-2.550976996-3.174433232-2.363736314-1.750861161-0.57801417-0.0689867451.771081887-1.431474737-0.1892182121.765637799-0.45175314-0.568249023-0.611967617-1.476054231-2.2292943311.177443672-0.440214504-0.698190746
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10701 is not tested in classification assay
Integrated Annotations for CG10701 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
establishment or maintenance of epithelial cell apical/basal polarityGO:0045197inferred from mutant phenotype
establishment or maintenance of polarity of larval imaginal disc epithelium
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from direct assay
fusome
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
cytoskeletal protein bindingGO:0008092inferred from sequence or structural similarity
actin binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10701 in FlyBase
FLIGHTClick here to see CG10701 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10701 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10701
Entrez GeneEntrez Gene page for CG10701
UniprotUniprot page for CG10701

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)