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Gene Page - CG Number : CG10718
Gene Summary - CG10718:

CG10718: The gene nebbish is referred to in FlyBase by the symbol Dmel\neb (CG10718, FBgn0004374). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein phosphatase 1 binding. There is experimental evidence that it is involved in the biological process: mitotic chromosome condensation; mitotic cell cycle, embryonic; meiosis; ovarian follicle cell development; regulation of cell cycle; mitotic sister chromatid segregation. 51 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system; organ system subdivision; external compound sense organ; adult; multicellular structure; sense organ; adult segment; peripheral nervous system; nuclear part; spermatozoon; cytoplasmic part; humeral trabecule. It has one annotated transcript and one annotated polypeptide. Protein features are: Forkhead-associated (FHA) domain; Kinesin, motor domain; Kinesin, motor region, conserved site; SMAD/FHA domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult male stages.

Gene summary for CG10718 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10718:CG10718 is not perturbed in primary screen.
CG10718 is perturbed in following parameters in classification assay (fluid): NuCellD-(fld) NuCirc+(fld) NuFluct-(fld)
CG10718 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10718.
Cell Count:
CG_NumberCategoryR1R2R3
CG10718Primary screen5341464
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10718:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20143-0.8504328771.2928357121.0452807351.0065170810.5683031590.2452929420.5618170860.241389316-0.142627725-1.422111951-1.048841036-0.05041869-0.667938042-0.8939523210.547232686-0.759515744-1.352464206-1.310741251-2.195295807-0.085371831-0.617163620.82900845-0.640687732
202183-0.514672065-1.629223629-0.407309139-2.376944462-2.949855268-1.479367426-1.866343053-1.927445707-4.094798025-1.326860682-1.655351714-0.468431221-1.708841781-1.086744849-0.49393397-3.328479707-2.210650093-2.437897143-2.678459885-4.133966319-0.655497984-1.692073997-1.160665325
203932.946711230.2417854430.0277393440.7451661030.5807168790.201337340.141671830.3488458961.0424602463.5674096962.165770831.424184672.1145166522.4799598362.1680210711.3569167761.5246867311.0073235341.4512806470.802853152-0.119852542-0.6298661670.416564603
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10718Slide18C0.8720.6521.3331.135
CG10718Slide18O0.1171.4231.1341.164
CG10718Slide18P0.9120.5421.2161.157
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10718 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mitotic chromosome condensationGO:0007076inferred from mutant phenotype
ovarian follicle cell development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
kinesin complexGO:0005871inferred from sequence or structural similarity
heterochromatin
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein phosphatase 1 bindingGO:0008157inferred from physical interaction with Pp1-87B
microtubule motor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10718 in FlyBase
FLIGHTClick here to see CG10718 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10718 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10718
Entrez GeneEntrez Gene page for CG10718
UniprotUniprot page for CG10718

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)