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Gene Page - CG Number : CG10719
Gene Summary - CG10719:

CG10719: The gene brain tumor is referred to in FlyBase by the symbol Dmel\brat (CG10719, FBgn0010300). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; translation repressor activity. There is experimental evidence for 17 unique biological process terms, many of which group under: biological regulation; system development; cellular component organization or biogenesis; regulation of neurogenesis; cell fate commitment; neuron differentiation; cell proliferation; cellular process; regulation of developmental process; ncRNA metabolic process; neuroblast fate commitment; regionalization; gene expression; multicellular organism reproduction. 109 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: multicellular structure; organ system; anatomical structure; adult; organ system subdivision; imaginal precursor; external compound sense organ; portion of tissue; adult segment; ovariole; embryonic/larval imaginal precursor; thoracic segment; abdominal segment; sense organ; non-connected developing system. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: NHL repeat; NHL repeat, subgroup; Six-bladed beta-propeller, TolB-like; Zinc finger, B-box. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10719 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10719:CG10719 is not perturbed in primary screen.
CG10719 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10719.
Cell Count:
CG_NumberCategoryR1R2R3
CG10719Primary screen72066465
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10719:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20144-0.6984625180.9485376262.2890472-0.219221383-0.4197911761.1227567582.91856831.3730326143.6487821721.7872845462.92965354-0.374365860.6653050940.2840218340.1835068650.7857329243.7000033086.8847543944.3615659374.5398372220.1180813617.7496692263.088744001
2021821.8163169753.013475140.969183753-0.596548207-1.383313411-0.7801467192.257982867-1.450186082-0.844416332-1.220804438-0.988719703-0.903128525-1.939776637-1.109821479-0.215932211-1.515124527-0.314292519-0.1247447770.1554964960.157924386-0.08638719-0.6794532040.479294126
203920.5172874860.011685319-0.246038512-0.570076190.3138386760.4176633550.6567033270.338925403-0.1762899983.0460512750.5547357061.5360965941.8027966410.8634613952.5223183381.0563413920.0013677780.900496293-0.176117847-0.2606156480.488187979-0.4812200551.390799929
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10719 is not tested in classification assay
Integrated Annotations for CG10719 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
rRNA metabolic processGO:0016072inferred from mutant phenotype
rRNA transcription
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737inferred from direct assay
basal cortex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein bindingGO:0005515inferred from physical interaction with nos
translation repressor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10719 in FlyBase
FLIGHTClick here to see CG10719 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10719 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10719
Entrez GeneEntrez Gene page for CG10719
UniprotUniprot page for CG10719

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)