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Gene Page - CG Number : CG10737
Gene Summary - CG10737:

CG10737: This gene is referred to in FlyBase by the symbol Dmel\CG10737 (FBgn0034420). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: diacylglycerol binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: intracellular signal transduction. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 12 annotated transcripts and 12 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Protein kinase C-like, phorbol ester/diacylglycerol binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.

Gene summary for CG10737 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10737:CG10737 is perturbed in following parameters in primary screen: Fint3 Fmph2
CG10737 is not perturbed in classification assay (fluid).
CG10737 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10737.
Cell Count:
CG_NumberCategoryR1R2R3
CG10737Primary screen750229369
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10737:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20151-0.3348840361.7878257313.8594009590.7653100263.3571862712.9172346913.7791787482.1241593042.276475713-0.4084535870.44381468-0.7151262572.2704252081.730647634-0.0808965991.378859293-2.234620381-0.626661223-2.0332225854.0093729411.0287755770.8820758512.343340296
2022051.8211244661.8190079460.8609885231.260688107-0.38115829-0.1258092422.972981272-0.39358920.676989889-0.1517942420.213853245-0.4741110630.156336047-0.519976919-0.022896638-0.712445585-0.0828733070.907741712-0.0195006960.891433814-0.320062297-0.4375917230.21190229
2031158.736079745.3785319344.3869026971.9530816012.4401901483.0019575627.4049775222.1408644331.7114919130.098072421-0.759796961-0.5674497050.302110080.61432579-0.4185661680.3292307650.6186587950.4803743830.9511646861.970963578-0.428380562-0.3604449970.396500385
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10737Slide8C0.3330.9010.7711.037
CG10737Slide8O0.1711.0761.0081.135
CG10737Slide8P0.6060.8960.8361.112
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG10737 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
intracellular signal transductionGO:0035556inferred from electronic annotation with InterPro:IPR002219
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
diacylglycerol bindingGO:0019992inferred from sequence or structural similarity with InterPro:IPR002219
Other annotations
DatabaseLink
FlyBaseClick here to see CG10737 in FlyBase
FLIGHTClick here to see CG10737 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10737 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10737
Entrez GeneEntrez Gene page for CG10737
UniprotUniprot page for CG10737

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)