Gene Page - CG Number : CG10738

Gene Summary - CG10738:

CG10738: This gene is referred to in FlyBase by the symbol Dmel\CG10738 (FBgn0036368). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: receptor activity; guanylate cyclase activity. There is experimental evidence that it is involved in the biological process: Golgi organization; positive regulation of cell proliferation; negative regulation of cell size; positive regulation of mitotic cell cycle. 6 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Adenylyl cyclase class-3/4/guanylyl cyclase; Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site; Extracellular ligand-binding receptor; Haem NO binding associated; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages.

Gene summary for CG10738 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10738:

CG10738 is not perturbed in primary screen.
CG10738 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10738.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10738	Primary screen	477	294	534

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10738:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
20	1	52	0.195534408	2.846637593	4.205089035	1.585142078	0.228790854	0.24302009	0.607051472	0.366912088	0.767384334	0.328281066	1.217683877	-0.893721974	-0.529715662	-0.54683456	-0.353589775	0.022522203	-0.264781331	-0.101144656	-0.316534067	2.249785606	1.175093789	3.561046006	2.706653436
20	2	204	-0.678968055	-0.24863528	-0.063228411	0.185195658	-0.309665641	0.51020356	1.622511177	0.281078774	0.630251926	-0.30001966	0.099806666	0.376118574	0.305751259	-0.292545551	0.305268381	-0.333287378	-0.282641984	0.982400286	-0.519007746	1.02436014	-0.325157334	1.292635504	-0.11768803
20	3	114	0.508747134	-0.008674584	0.030455667	0.533370566	1.655476472	1.747965629	2.15116228	1.856746734	2.061226018	1.8157293	1.215705495	0.545250875	2.485335967	1.566561297	-0.469253777	1.177933436	1.278577716	0.548242906	1.506693149	2.047124799	-0.171173175	-0.405262347	0.339769361

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10738 is not tested in classification assay

Integrated Annotations for CG10738 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
signal transduction	GO:0007165	inferred from sequence or structural similarity Golgi organization

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
plasma membrane	GO:0005886	inferred from sequence or structural similarity

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
guanylate cyclase activity	GO:0004383	inferred from sequence or structural similarity receptor activity

Other annotations

Database	Link
FlyBase	Click here to see CG10738 in FlyBase
FLIGHT	Click here to see CG10738 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10738 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10738
Entrez Gene	Entrez Gene page for CG10738
Uniprot	Uniprot page for CG10738

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)