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Gene Page - CG Number : CG10749
Gene Summary - CG10749:

CG10749: This gene is referred to in FlyBase by the symbol Dmel\CG10749 (FBgn0036328). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: L-malate dehydrogenase activity. Based on sequence similarity, it is predicted to be involved in the biological process: tricarboxylic acid cycle. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: L-lactate/malate dehydrogenase; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; Lactate/malate dehydrogenase, C-terminal; Lactate/malate dehydrogenase, N-terminal; Malate dehydrogenase, active site; Malate dehydrogenase, type 1; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed in adult male stages.

Gene summary for CG10749 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10749:CG10749 is not perturbed in primary screen.
CG10749 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10749.
Cell Count:
CG_NumberCategoryR1R2R3
CG10749Primary screen614288477
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10749:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20157-0.2670291231.4663624531.896403919-0.526833684-0.2033751260.7954240541.8349498980.8803585970.8640601210.19598996-0.274191015-0.4405371530.053853436-0.058977504-0.201462908-0.542736637-0.310922002-0.48257981-0.930519671.284006118-0.5089972640.326544281-0.281222612
2021991.3512650430.906536-0.132481905-0.343815741-0.091889596-1.183765012-1.327263887-0.080263856-0.59729016-0.2203717650.2182414650.440846231.1632793720.465746322-0.471482377-0.190566351.3420957640.1344730610.030721654-0.220438239-0.082731287-0.497038613-0.860748986
203109-0.6618432670.4664909191.424609195-0.5091026711.3641893261.8142501692.125239511.6435830131.922618154-0.3800594690.043630274-0.3930629270.112623986-0.125491092-0.1899661750.56487407-0.0442889250.1605205090.1517469132.0076701990.3294794650.4914136650.316770108
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10749 is not tested in classification assay
Integrated Annotations for CG10749 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
tricarboxylic acid cycleGO:0006099inferred from sequence or structural similarity with UniProtKB:P40926
cellular carbohydrate metabolic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
mitochondrionGO:0005739inferred from sequence or structural similarity with MGD:Mor1; MGI:MGI:97050
mitochondrial matrix
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
L-malate dehydrogenase activityGO:0030060inferred from sequence or structural similarity with MGD:Mor1; MGI:MGI:97050
L-malate dehydrogenase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10749 in FlyBase
FLIGHTClick here to see CG10749 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10749 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10749
Entrez GeneEntrez Gene page for CG10749
UniprotUniprot page for CG10749

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)