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Gene Page - CG Number : CG10754
Gene Summary - CG10754:

CG10754: This gene is referred to in FlyBase by the symbol Dmel\CG10754 (FBgn0036314). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: mitotic spindle organization; neurogenesis. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Cactin C-terminal domain; Zinc finger, C2H2-like; Zinc finger, C2H2-type matrin; Zinc finger, U1-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10754 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10754:CG10754 is perturbed in following parameters in primary screen: Tint2 Tmph2 Tmph3
CG10754 is not tested in classification assay (fluid).
CG10754 is perturbed in following parameters in classification assay (transferrin): Fint1+ Fint2+ Fint3+ Fint4- NuSize-(tfr) Tint1- Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10754.
Cell Count:
CG_NumberCategoryR1R2R3
CG10754Primary screen41531050
CG10754Secondary assay9321078848
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10754:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201590.221419507-0.100589951-0.033095822-0.293545867-0.7982802910.2200883181.0651101090.0672372812.5844728257.0819424316.4501044650.117848395-0.191635167-0.40977250712.28538406-0.0944845479.79466383911.878551528.1493224034.132935640.4021026230.523726181-0.591553668
2021971.0793690153.9968727490.0626079610.964309507-0.2662740120.9831021352.8289601841.0422476832.1024442332.862600811.946035620.8814759223.1078736112.8347653972.4845973120.4099461092.5942603253.3878403813.3381831452.154986591-0.385276212-0.7806610720.250142767
2031071.4878215490.831064229-1.411166962-0.639635395-4.621572765-5.289763289-5.788664122-4.914300509-4.689516205-0.909283145-3.348293945-0.663896602-3.753952582-3.0790613991.090898826-1.87006467-2.990350935-1.275117004-3.514833243-5.563459087-1.255081812-1.251423744-1.168884168
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10754Slide1F0.0381.0631.0991.160
CG10754Slide1O0.6191.0181.0250.855
CG10754Slide1T0.2500.8830.9770.660
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10754 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
nuclear mRNA splicing, via spliceosomeGO:0000398inferred from sequence or structural similarity with HGNC_gene:SF3A2; HGNC:10766; OMIM:600796
nuclear mRNA splicing, via spliceosome
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
spliceosomal complexGO:0005681inferred from sequence or structural similarity with HGNC_gene:SF3A2; HGNC:10766; OMIM:600796
U2 snRNP
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
zinc ion bindingGO:0008270inferred from electronic annotation with InterPro:IPR000690, InterPro:IPR003604, InterPro:IPR015880
nucleic acid binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10754 in FlyBase
FLIGHTClick here to see CG10754 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10754 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10754
Entrez GeneEntrez Gene page for CG10754
UniprotUniprot page for CG10754

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)