Gene Page - CG Number : CG10772

Gene Summary - CG10772:

CG10772: The gene Furin 1 is referred to in FlyBase by the symbol Dmel\Fur1 (CG10772, FBgn0004509). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: synaptic target recognition. 33 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Furin-like repeat; Galactose-binding domain-like; Growth factor, receptor; Peptidase S8, subtilisin, Asp-active site; Peptidase S8, subtilisin, His-active site; Peptidase S8, subtilisin, Ser-active site; Peptidase S8, subtilisin-related; Peptidase S8/S53, subtilisin/kexin/sedolisin; Proprotein convertase, P; Proteinase inhibitor, propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early pupal stages, in adult female stages.

Gene summary for CG10772 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10772:

CG10772 is not perturbed in primary screen.
CG10772 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10772.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10772	Primary screen	702	8	250

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10772:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
20	1	68	-0.553202059	0.619777985	-0.168364553	-0.593783638	1.068833783	0.552823231	0.013803899	0.943164238	1.64869578	0.164095557	0.101408175	-0.411285178	0.346047985	0.295494069	-0.294095301	1.113125078	0.980200365	0.148869936	1.068704945	1.613175661	-0.267763033	3.724990739	2.400929619
20	2	218	-0.317520094	-1.818688491	-1.006765089	-0.187746385	-3.343121482	-2.545713311	-2.979440225	-1.653918053	-3.612314094	-0.523808208	-1.898204991	0.094416728	-0.896193514	-1.284099633	0.105414473	-2.517611506	-1.006885178	-1.915215191	-0.73344609	-3.024980136	-1.768616016	-1.979802364	-1.910791444
20	3	68	1.520590532	2.103652549	2.415892649	0.014914443	-0.189655479	0.32212453	3.449241557	-0.025077432	0.34679615	0.795934613	1.740434783	-0.54357274	-1.010268797	-0.182054014	0.42961899	1.866669151	1.225649295	1.008594725	0.087760544	0.415271298	-0.595476461	-0.427082529	0.294464552

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10772 is not tested in classification assay

Integrated Annotations for CG10772 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
proteolysis	GO:0006508	non-traceable author statement proteolysis

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
plasma membrane	GO:0005886	inferred from sequence or structural similarity plasma membrane

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
serine-type endopeptidase activity	GO:0004252	inferred from direct assay serine-type endopeptidase activity

Other annotations

Database	Link
FlyBase	Click here to see CG10772 in FlyBase
FLIGHT	Click here to see CG10772 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10772 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10772
Entrez Gene	Entrez Gene page for CG10772
Uniprot	Uniprot page for CG10772

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)