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Gene Page - CG Number : CG10776
Gene Summary - CG10776:

CG10776: The gene wishful thinking is referred to in FlyBase by the symbol Dmel\wit (CG10776, FBgn0024179). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transforming growth factor beta receptor activity, type II. There is experimental evidence that it is involved in the biological process: neuromuscular synaptic transmission; lateral inhibition; neuromuscular junction development. 39 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; posterior crossvein; NMJ bouton; bouton; chaeta; neuromuscular junction; embryonic/larval neuromuscular junction; postsynaptic membrane; synapse; embryonic/larval muscle system. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; TGF-beta receptor/activin receptor, type I/II. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages.

Gene summary for CG10776 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10776:CG10776 is not perturbed in primary screen.
CG10776 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10776.
Cell Count:
CG_NumberCategoryR1R2R3
CG10776Primary screen5577336
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10776:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201690.2335897860.5009783891.09684018-0.8111080540.2833818350.4019740190.5617055880.6929322290.928369477-0.82365166-1.4979665830.440256651-0.0393251990.299720937-0.1203549910.082172339-0.252715195-0.6421088710.4968205280.939426907-0.175996097-0.1232324510.17233026
202217-0.71673676-0.6345379341.101216646-1.107541681-2.499760424-0.969093562-1.099087437-2.835742895-2.726261545-0.565699929-2.837964993-1.690857217-3.609489593-0.626074526-0.420070529-1.9592694730.022218337-0.8441900640.321146027-2.089990253-0.513134718-1.55162098-0.947364962
203670.4614020950.5365691420.4184100131.5719486340.5167192180.9504728324.285655580.8797008811.247746022.292322873.2008653820.760582534.3736548443.5538549120.0069465321.8120035263.6011250481.7949196861.8968111221.1796265741.85301955-0.665228741-0.646113851
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10776 is not tested in classification assay
Integrated Annotations for CG10776 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein phosphorylationGO:0006468inferred from sequence or structural similarity
signal transduction
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from sequence or structural similarity
plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
transforming growth factor beta receptor activity, type IIGO:0005026inferred from sequence or structural similarity
transforming growth factor beta receptor activity, type II
Other annotations
DatabaseLink
FlyBaseClick here to see CG10776 in FlyBase
FLIGHTClick here to see CG10776 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10776 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10776
Entrez GeneEntrez Gene page for CG10776
UniprotUniprot page for CG10776

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)