Gene Page - CG Number : CG10806

Gene Summary - CG10806:

CG10806: The gene Na⁺/H⁺ hydrogen antiporter 1 is referred to in FlyBase by the symbol Dmel\Nha1 (CG10806, FBgn0031865). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sodium:hydrogen antiporter activity. There is experimental evidence that it is involved in the biological process: renal sodium ion transport. 6 alleles are reported. The phenotype of these alleles is annotated with: adult Malpighian tubule. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cation/H+ exchanger. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during late larval stages.

Gene summary for CG10806 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10806:

CG10806 is perturbed in following parameters in primary screen: NuCirc NuSize
CG10806 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10806.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10806	Primary screen	649	929	895

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10806:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
20	1	79	2.138088298	-0.880286967	-0.792546172	-0.651594991	0.466304378	-2.112756287	-0.941270912	-1.08585826	0.330737751	0.13345691	0.651186145	0.209706643	1.928179059	-0.501945111	2.445848777	1.034061466	0.838657964	2.392271558	1.649047609	-0.160875019	-0.685302411	1.871706997	1.145407864
20	2	237	0.447094817	2.389629146	4.005886313	0.714189647	2.580449358	4.633355999	3.701067181	4.31868474	3.552307146	-0.422814995	0.559608077	0.038786313	0.162763135	2.174999894	-0.167171311	1.826345149	0.158185597	0.208480952	-0.426415456	3.718990388	0.328080676	5.632034762	3.605815821
20	3	87	0.026591185	0.393777776	-0.196098128	0.093382663	2.331273139	-0.61873215	1.060603984	-0.86564695	-0.084835984	0.485203963	-0.18119443	-0.064629194	-0.160408408	0.05168772	0.666154304	1.759846601	0.570874853	-0.273776799	-0.528899047	0.314972396	1.27661363	4.996292323	5.387792411

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10806 is not tested in classification assay

Integrated Annotations for CG10806 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
renal sodium ion transport	GO:0003096	inferred from mutant phenotype transmembrane transport

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
brush border	GO:0005903	inferred from direct assay integral to membrane

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
sodium:hydrogen antiporter activity	GO:0015385	inferred from sequence or structural similarity with EMBL:AE000854 sodium:hydrogen antiporter activity

Other annotations

Database	Link
FlyBase	Click here to see CG10806 in FlyBase
FLIGHT	Click here to see CG10806 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10806 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10806
Entrez Gene	Entrez Gene page for CG10806
Uniprot	Uniprot page for CG10806

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)