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Gene Page - CG Number : CG10811
Gene Summary - CG10811:

CG10811: The gene eukaryotic translation initiation factor 4G is referred to in FlyBase by the symbol Dmel\eIF4G (CG10811, FBgn0023213). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: eukaryotic initiation factor 4E binding; RNA binding; RNA 7-methylguanosine cap binding. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; G1/S transition of mitotic cell cycle; mitotic cell cycle G2/M transition DNA damage checkpoint; mitosis; mitotic spindle organization; translation. 5 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Armadillo-type fold; Initiation factor eIF-4 gamma, MA3; MIF4-like, type 1/2/3; MIF4G-like, type 3; W2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.

Gene summary for CG10811 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10811:CG10811 is perturbed in following parameters in primary screen: NuCirc NuFluct NuSize
CG10811 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10811.
Cell Count:
CG10811Primary screen8021160792
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10811:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10811 is not tested in classification assay
Integrated Annotations for CG10811 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
translational initiationGO:0006413inferred from sequence or structural similarity
mitotic spindle elongation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytosolGO:0005829inferred from sequence or structural similarity
eukaryotic translation initiation factor 4F complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
translation initiation factor activityGO:0003743inferred from sequence or structural similarity
RNA 7-methylguanosine cap binding
Other annotations
FlyBaseClick here to see CG10811 in FlyBase
FLIGHTClick here to see CG10811 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10811 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10811
Entrez GeneEntrez Gene page for CG10811
UniprotUniprot page for CG10811

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)