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Gene Page - CG Number : CG10837
Gene Summary - CG10837:

CG10837: The gene Eukaryotic initiation factor 4B is referred to in FlyBase by the symbol Dmel\eIF-4B (CG10837, FBgn0020660). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: cell proliferation; translational initiation; positive regulation of JAK-STAT cascade. 9 alleles are reported. The phenotypes of these alleles are annotated with: eye; ommatidium. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.

Gene summary for CG10837 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10837:CG10837 is not perturbed in primary screen.
CG10837 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10837.
Cell Count:
CG_NumberCategoryR1R2R3
CG10837Primary screen672464744
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10837:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201912.4742424570.4000673760.211016564-0.349816071-0.046262887-2.717498631-0.101872947-1.9601002150.564639187-0.2525514630.8567231940.132083388-0.4533029910.4166290360.2561594130.518774221-0.3807846191.657732526-0.5399887190.6068682570.3862994980.034844507-0.642301993
2022550.782447277-0.4023404480.206472009-0.5036918760.6896781851.106775426-0.1388108630.7137144640.512265551-0.88475913-0.0795645990.6088442621.8534156081.607703348-0.332642609-0.0759493932.414845908-0.9745324142.2028992180.300182531-0.2166257510.3852356560.288757394
203450.004716332-0.434199114-0.28382056-0.6443069931.4648917511.3007080490.5157556351.6197619262.214693817-0.8101779550.419180394-0.5661334760.346936767-0.6815309740.1167027840.88480260.6488988630.8826542970.3997121821.1791212210.2680790525.8875217892.620654884
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10837 is not tested in classification assay
Integrated Annotations for CG10837 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
translational initiationGO:0006413inferred from physical interaction with eIF-4E
translational initiation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytosolGO:0005829inferred from physical interaction with eIF-4E
cytosol
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
translation initiation factor activityGO:0003743inferred from physical interaction with eIF-4E
mRNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10837 in FlyBase
FLIGHTClick here to see CG10837 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10837 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10837
Entrez GeneEntrez Gene page for CG10837
UniprotUniprot page for CG10837

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)