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Gene Page - CG Number : CG10844
Gene Summary - CG10844:

CG10844: The gene Ryanodine receptor 44F is referred to in FlyBase by the symbol Dmel\Rya-r44F (CG10844, FBgn0011286). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ryanodine-sensitive calcium-release channel activity. There is experimental evidence that it is involved in the biological process: muscle contraction; regulation of hemocyte proliferation. 16 alleles are reported. The phenotypes of these alleles are annotated with: larva; larval head; embryonic/larval dorsal vessel; presumptive embryonic/larval muscle system; embryonic/larval visceral muscle; embryonic/larval muscle system. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: B30.2/SPRY domain; Concanavalin A-like lectin/glucanases superfamily; EF-hand-like domain; Inositol 1,4,5-trisphosphate/ryanodine receptor; Intracellular calcium-release channel; Ion transport domain; MIR motif; RyR/IP3R Homology associated domain; Ryanodine Receptor TM 4-6; Ryanodine receptor; Ryanodine receptor Ryr; Ryanodine receptor-related; SPla/RYanodine receptor SPRY; SPla/RYanodine receptor subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages.

Gene summary for CG10844 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10844:CG10844 is perturbed in following parameters in primary screen: NuSize
CG10844 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10844.
Cell Count:
CG_NumberCategoryR1R2R3
CG10844Primary screen833652481
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10844:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201950.7125707260.9852661560.584522910.5776017760.713379034-2.096902647-0.097886317-1.452209530.1197405670.6083875971.0787546150.510598209-0.106199440.6421366012.7972071410.3237060981.8104242710.7464076740.7790190821.9250865610.3237974353.5716843352.719212315
2022513.26627012-0.0984024150.1034196331.211875270.9334902690.3572543921.2234269380.455702682-0.009976702-0.157230749-0.308118092-0.4962916540.015013388-0.4409961340.1418369670.438269689-0.402842273-0.7928431491.449815826-0.508386149-0.3842178963.9495592210.415054254
20341-0.517130932-0.665311813-0.328533859-0.4017514090.0213838840.832959452-0.1754454110.8367321731.592343485-0.1085591411.5910124490.1109393790.9163350270.859622391-0.573701316-0.0334820590.8172139032.6822837010.2637102061.3650259830.3353412845.1113225370.319762141
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10844 is not tested in classification assay
Integrated Annotations for CG10844 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
calcium ion transportGO:0006816traceable author statement
muscle contraction
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to membraneGO:0016021non-traceable author statement
endoplasmic reticulum membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
ryanodine-sensitive calcium-release channel activityGO:0005219traceable author statement
ryanodine-sensitive calcium-release channel activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10844 in FlyBase
FLIGHTClick here to see CG10844 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10844 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10844
Entrez GeneEntrez Gene page for CG10844
UniprotUniprot page for CG10844

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)