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Gene Page - CG Number : CG10850
Gene Summary - CG10850:

CG10850: The gene imaginal discs arrested is referred to in FlyBase by the symbol Dmel\ida (CG10850, FBgn0041147). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: mitotic anaphase-promoting complex activity. There is experimental evidence that it is involved in the biological process: imaginal disc development; positive regulation of mitotic metaphase/anaphase transition; neurogenesis. 13 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; imaginal precursor; multicellular structure; cell cycle; cellular component organization or biogenesis; cell cycle process; eo support cell; salivary gland imaginal ring; organ system subdivision; sense organ; tracheal system; larval head segment; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: Anaphase-promoting complex subunit 5,TPR-containing domain; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages.

Gene summary for CG10850 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10850:CG10850 is perturbed in following parameters in primary screen: Fclc Fmph3 Tclc Tint4
CG10850 is perturbed in following parameters in classification assay (fluid): Rto1- SP_Fint1-
CG10850 is perturbed in following parameters in classification assay (transferrin): Fmph1- Fmph3- Okt+(tfr) Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint4- Tmph1-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10850.
Cell Count:
CG_NumberCategoryR1R2R3
CG10850Primary screen796940958
CG10850Secondary assay8969051063
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10850:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201991.549515457-0.135250695-0.1555421950.3507863240.7661250541.8239533631.5011555691.682412961.7343129541.202209993.092833810.1814053460.0493721570.3111477131.0881561981.2967747261.3640597222.8560395980.6720275892.1477793680.6564388362.9439130141.869851875
2022470.876123216-0.162636422-0.0275404010.3170418621.1876451912.5044649212.3182442963.0237497093.2505181240.7656808563.579177850.6719830711.5057795470.6784845593.9715210862.3850672530.9934277561.6139446311.0027080013.2015075084.5332805752.5633385822.691139503
20337-0.0200003860.5667140760.168516141.300086791.251884583.1001236181.9391236613.1475984224.8144204412.3402762284.030893236-0.2012542351.7396464062.6536409920.4320760341.3414971543.3329182188.654465913.9165655254.7416619432.9759680337.6723919125.071925149
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10850Slide20C0.9830.9721.0670.955
CG10850Slide20O0.6570.9981.0131.149
CG10850Slide20P0.3400.9870.9800.817
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10850Slide1F0.4671.2681.1661.083
CG10850Slide1O0.0521.7801.5611.466
CG10850Slide1T0.1550.4650.5240.227
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10850 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mitotic anaphaseGO:0000090non-traceable author statement
imaginal disc development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
anaphase-promoting complexGO:0005680non-traceable author statement
anaphase-promoting complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
bindingGO:0005488inferred from electronic annotation with InterPro:IPR011990
Other annotations
DatabaseLink
FlyBaseClick here to see CG10850 in FlyBase
FLIGHTClick here to see CG10850 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10850 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10850
Entrez GeneEntrez Gene page for CG10850
UniprotUniprot page for CG10850

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)