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Gene Page - CG Number : CG10868
Gene Summary - CG10868:

CG10868: The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn0004882). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: oocyte anterior/posterior axis specification; regulation of oskar mRNA translation; mRNA polyadenylation; pole plasm oskar mRNA localization; germ cell development; oocyte dorsal/ventral axis specification. 32 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: multicellular structure; anatomical structure; organ system; multi-tissue structure; ovariole; nuclear part; eo support cell; acellular anatomical structure; organ system subdivision; cell periphery; female organism; sense organ; condensed nuclear chromosome; adult segment. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in stages of adults of both sexes.

Gene summary for CG10868 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10868:CG10868 is not perturbed in primary screen.
CG10868 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10868.
Cell Count:
CG_NumberCategoryR1R2R3
CG10868Primary screen361593385
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10868:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2011054.281329404-0.265728712-1.0453493711.172210593-1.062011694-2.695320138-1.809129918-2.418479584-1.9141536110.0018918630.05905841-0.921473358-0.2314111371.067192074-0.40219887-0.351407488-0.0272139510.8664221440.00071807-1.974577030.987664316-0.5030341431.832791902
202241-0.08962957-0.36649631-0.332487208-0.1432288580.9615506461.2723429990.8002533921.4178788222.22522150128.64605608-0.02200865824.169664539.1386321630.48454345-0.044054062-0.081823796-1.217924009-0.314645423-1.0801719182.618742263-0.0991505191.6994857770.594967103
203310.812335796-0.574514204-0.1109220460.464051158-0.7764434420.5177567960.2713081470.3647107461.0395887020.1918114233.2321074840.218193766-0.730936821-0.3209948331.1189367161.0935785431.4032081675.024514724-0.241374130.5417542384.0604842814.5149246832.842496294
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10868 is not tested in classification assay
Integrated Annotations for CG10868 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
oocyte dorsal/ventral axis specificationGO:0007310inferred from mutant phenotype
oocyte anterior/posterior axis specification
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737inferred from direct assay
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
uridine-rich cytoplasmic polyadenylylation element bindingGO:0017131inferred from sequence or structural similarity with UniProtKB:Q91572
mRNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10868 in FlyBase
FLIGHTClick here to see CG10868 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10868 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10868
Entrez GeneEntrez Gene page for CG10868
UniprotUniprot page for CG10868

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)