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Gene Page - CG Number : CG10895
Gene Summary - CG10895:

CG10895: The gene loki is referred to in FlyBase by the symbol Dmel\lok (CG10895, FBgn0019686). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tau-protein kinase activity. There is experimental evidence that it is involved in the biological process: apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; germ cell programmed cell death; response to DNA damage stimulus; germ cell development; intrinsic apoptotic signaling pathway in response to DNA damage response; DNA damage checkpoint. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye; egg chamber. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Forkhead-associated (FHA) domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SMAD/FHA domain; Serine/threonine- / dual-specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG10895 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10895:CG10895 is not perturbed in primary screen.
CG10895 is not tested in classification assay (fluid).
CG10895 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint1+ Fint4- Okt+(tfr) Tint1+ Tint2+ Tint3+ Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10895.
Cell Count:
CG_NumberCategoryR1R2R3
CG10895Primary screen752748450
CG10895Secondary assay106313571090
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10895:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2011182.3340575780.316672898-0.2648677210.129609575-0.549838045-5.310503734-0.338227961-3.89716673-1.4351503310.8726905470.5713491020.3458780590.0203707010.298947811.2362068120.958439876-0.3686280340.0255482-0.520499729-1.2916009073.0273549231.8217452040.609465219
202258-0.518136285-0.482658002-0.534510332-0.354918372.0865532341.4942635030.8102429071.7417689681.641145667-0.3571675360.170495980.1196409783.6929616381.614048356-0.6962720451.449308913-0.924765884-0.4335416430.5042575361.01940523-0.0870001662.6824366271.930848209
203481.0298461780.195502008-0.108362796-0.773115863-0.0900955961.138819110.3481654291.0840117580.063503547-0.828139149-0.032087808-0.8497544970.4824501710.9261404340.0883997720.246994644-0.909905703-1.511446751-0.237485560.0729887620.4265115540.600068327-0.241633422
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10895Slide1F0.0451.0861.1511.091
CG10895Slide1O0.0061.3461.3671.242
CG10895Slide1T0.6480.9401.1411.089
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10895 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
germ cell developmentGO:0007281inferred from expression pattern
protein phosphorylation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737non-traceable author statement
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein serine/threonine kinase activityGO:0004674non-traceable author statement
protein serine/threonine kinase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10895 in FlyBase
FLIGHTClick here to see CG10895 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10895 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10895
Entrez GeneEntrez Gene page for CG10895
UniprotUniprot page for CG10895

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)