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Gene Page - CG Number : CG10908
Gene Summary - CG10908:

CG10908: The gene Derlin-1 is referred to in FlyBase by the symbol Dmel\Der-1 (CG10908, FBgn0031376). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peptidase activity. Based on sequence similarity, it is predicted to be involved in the biological process: ER-associated protein catabolic process; misfolded or incompletely synthesized protein catabolic process. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Derlin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed in adult male stages.

Gene summary for CG10908 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10908:CG10908 is not perturbed in primary screen.
CG10908 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10908.
Cell Count:
CG_NumberCategoryR1R2R3
CG10908Primary screen289386519
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10908:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201123-0.180285552-0.872342289-0.664675778-0.496579789-0.944943385-3.603842587-2.796351343-2.729493703-3.4124246385.464717371-0.4854135272.7396469694.591098944.8623099381.091980941-1.024239788-1.087001328-0.369872655-0.177817267-3.5488276541.561420592-0.409718731-0.824363958
2022830.8789954640.8953003310.2108121250.712494667-0.136829597-0.607870175-0.397710411-0.593698706-1.837224186-0.802061211-0.7786936490.5119519710.1024179420.3373883720.8228353530.0153621853.534039905-0.6226378761.272790796-1.738670046-0.6024504730.108366759-0.777899093
20313-0.5209040390.6166182840.5451116911.3604613450.5054579531.6200533080.1060268681.3413224560.948012085-0.695626570.1895932250.923535003-0.545733454-1.073367075-0.164748720.164860060.436926788-0.9121165660.0684716170.816013504-0.7811662582.2648695241.570201999
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10908 is not tested in classification assay
Integrated Annotations for CG10908 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
ER-associated protein catabolic processGO:0030433inferred from sequence or structural similarity with UniProtKB:P38307
misfolded or incompletely synthesized protein catabolic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
endoplasmic reticulum membraneGO:0005789inferred from sequence or structural similarity with UniProtKB:P38307
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
peptidase activityGO:0008233inferred from sequence or structural similarity with UniProtKB:P38307
Other annotations
DatabaseLink
FlyBaseClick here to see CG10908 in FlyBase
FLIGHTClick here to see CG10908 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10908 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10908
Entrez GeneEntrez Gene page for CG10908
UniprotUniprot page for CG10908

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)