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Gene Page - CG Number : CG10917
Gene Summary - CG10917:

CG10917: The gene four-jointed is referred to in FlyBase by the symbol Dmel\fj (CG10917, FBgn0000658). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-protein binding; protein kinase activity. There is experimental evidence that it is involved in the biological process: establishment of planar polarity; establishment of imaginal disc-derived wing hair orientation; cell-cell signaling; imaginal disc-derived wing vein specification; establishment of epithelial cell apical/basal polarity; regulation of tube length, open tracheal system; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; Wnt receptor signaling pathway, planar cell polarity pathway. 51 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: adult segment; organ system subdivision; organ system; appendage segment; thoracic segment; external compound sense organ; imaginal precursor; peripheral nervous system; embryonic/larval imaginal precursor; tracheal system; integumentary specialisation; metatarsus. It has one annotated transcript and one annotated polypeptide. Protein features are: Four-jointed box protein 1/four-jointed protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages.

Gene summary for CG10917 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10917:CG10917 is not perturbed in primary screen.
CG10917 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10917.
Cell Count:
CG_NumberCategoryR1R2R3
CG10917Primary screen791289529
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10917:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2011310.285503195-0.3864101660.20340193-0.12445590.106130393-1.1302465640.277609386-0.770652304-0.4276383772.8505047160.4611871760.182763130.4158551941.0954696711.2347233520.8807843240.0691500250.369952808-0.297091630.3597945870.6305880432.0265915810.304884751
202275-1.0504498610.196666028-0.245763473-0.391347343-0.893304199-0.418488792-1.250529968-0.411728893-2.0155430630.2241640720.2782662510.513082947-1.132975874-0.442369790.022977356-0.762877703-1.40938639-0.5963176910.041702588-2.502167114-0.4170609871.326442643-0.349242496
2035-0.1571430260.7704667060.559465446-0.604974503-0.858620944-2.572651334-0.834895692-3.070648147-1.723284609-0.551796537-0.4943219430.77996477-0.786244092-0.398748024-0.2084892930.525215040.066479783-0.377970877-0.077796715-1.9033236980.6138881664.2575728940.551618794
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10917 is not tested in classification assay
Integrated Annotations for CG10917 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
cell-cell signalingGO:0007267inferred from direct assay AND inferred from sequence or structural similarity
imaginal disc growth
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from direct assay AND inferred from sequence or structural similarity
plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein kinase activityGO:0004672inferred from direct assay
Wnt-protein binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10917 in FlyBase
FLIGHTClick here to see CG10917 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10917 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10917
Entrez GeneEntrez Gene page for CG10917
UniprotUniprot page for CG10917

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)