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Gene Page - CG Number : CG10923
Gene Summary - CG10923:

CG10923: The gene Kinesin-like protein at 67A is referred to in FlyBase by the symbol Dmel\Klp67A (CG10923, FBgn0004379). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: motor activity. There is experimental evidence that it is involved in the biological process: sister chromatid biorientation; centrosome separation; male meiosis chromosome segregation; chromosome segregation; mitotic spindle organization; cytokinesis; spindle elongation; microtubule polymerization; spindle assembly; male meiotic chromosome movement towards spindle pole. 15 alleles are reported. The phenotypes of these alleles are annotated with: spindle microtubule; S2 cell-line; spindle pole; spindle; cytoplasmic microtubule; astral microtubule. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Kinesin, motor domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG10923 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10923:CG10923 is perturbed in following parameters in primary screen: NuSize Tclc Tint4 Tmph2
CG10923 is not tested in classification assay (fluid).
CG10923 is perturbed in following parameters in classification assay (transferrin): Fint4+ Tint2+ Tint3+
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10923.
Cell Count:
CG_NumberCategoryR1R2R3
CG10923Primary screen662919858
CG10923Secondary assay96211781065
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10923:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201134-0.3215781660.228631423-0.38826452-0.0233837970.4726935631.0414035631.9578150571.1423660322.5511424763.2361185896.117547362-0.0449755431.1707224580.9956390841.2501014660.8353411153.2775371746.6968288494.5927196173.740994040.9537500170.7641448680.832544037
2022720.0236717240.364742191-0.1865613-0.4889472351.2428660922.3362475621.8968711362.4891886922.674914713-0.560459116-0.2017356350.0448419270.7259295580.774573830.3864483461.359752256-0.4143782320.231948911-0.9648455322.4721948951.369762387.0254853392.410722471
20320.0574637370.066123866-0.060738334-0.6667513010.6188611243.0542838281.9583555772.9087045813.535299781.1841380523.683642925-0.198522266-0.0975900380.8878649170.2416742481.3645409611.6502212675.0461005831.9662191054.0727361461.6315420046.1183501573.775201508
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10923Slide2F0.6711.0080.8551.042
CG10923Slide2O0.3191.1211.0360.998
CG10923Slide2T0.5611.0371.4080.890
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10923 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
microtubule-based movementGO:0007018inferred from sequence or structural similarity
centrosome separation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737inferred from direct assay
kinesin complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
motor activityGO:0003774inferred from direct assay AND inferred from sequence or structural similarity
microtubule motor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10923 in FlyBase
FLIGHTClick here to see CG10923 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10923 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10923
Entrez GeneEntrez Gene page for CG10923
UniprotUniprot page for CG10923

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)