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Gene Page - CG Number : CG10938
Gene Summary - CG10938:

CG10938: The gene Proteasome ╬▒5 subunit is referred to in FlyBase by the symbol Dmel\Pros╬▒5 (CG10938, FBgn0016697). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: cellular process. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Proteasome A-type subunit; Proteasome, alpha-subunit, N-terminal domain; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG10938 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10938:CG10938 is perturbed in following parameters in primary screen: Fclc Fint1 Fint2 Fint3 Fint4 Fmph1 Fmph2 Fmph3 Fnum NuCirc NuFluct NuSize Okt Tclc Tint1 Tint2 Tint3 Tint4 Tmph1 Tmph2 Tmph3
CG10938 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc- LP_Fmph1- LP_Fmph2- LP_Fmph3- LP_Fnum- NuCirc+(fld) NuSize-(fld) Okt+(fld) Rto3- SP_Fclc- SP_Fint1- SP_Fint2- SP_Fint3- SP_Fnum-
CG10938 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint1- Fmph2- Fnum- NuCellD+(tfr) NuCirc+(tfr) NuSize-(tfr) Okt+(tfr) Rto1-(tfr) Rto2-(tfr) Tclc- Tmph1- Tmph2- Tmph3- Tnum-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10938.
Cell Count:
CG_NumberCategoryR1R2R3
CG10938Primary screen9449901051
CG10938Secondary assay716610763
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10938:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
20114315.0011542110.648016319.7547595994.3831368183.30691230514.4696050616.6531513314.0441613410.85156887.9520750587.7603882410.4027274730.8011538950.65000495110.076767550.3289901725.96427791813.763138138.07548107313.773972464.2291796970.5874198731.095899123
2022933.5167187610.901517111.621911173.6660233913.3504684749.0050058110.801528339.8135718726.5089082061.9870176645.5638133840.343516092.3312070053.0911921891.518800851.9959832692.2985556035.9206587721.6564332788.56127362.6853290533.8496951473.439347803
2032310.7979689917.1377775317.081458234.8944557556.25018145121.1026100117.1898433530.5051208318.663407476.4038175518.701994839-0.4893461922.3051842812.3454920296.7110535091.26333217311.7556278219.8880824211.109305918.660029150.1730194195.06200556.140450046
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10938Slide10C0.1300.8770.8870.609
CG10938Slide10O0.0191.1311.2321.292
CG10938Slide10P0.0340.7600.6900.470
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10938Slide2F0.0180.5310.7040.714
CG10938Slide2O0.0371.0951.1861.264
CG10938Slide2T0.1400.3010.7310.853
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10938 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
ubiquitin-dependent protein catabolic processGO:0006511non-traceable author statement
cellular process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
proteasome complexGO:0000502non-traceable author statement
proteasome core complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
endopeptidase activityGO:0004175non-traceable author statement
threonine-type endopeptidase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10938 in FlyBase
FLIGHTClick here to see CG10938 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10938 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10938
Entrez GeneEntrez Gene page for CG10938
UniprotUniprot page for CG10938

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)