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Gene Page - CG Number : CG10952
Gene Summary - CG10952:

CG10952: The gene ether a go-go is referred to in FlyBase by the symbol Dmel\eag (CG10952, FBgn0000535). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: voltage-gated cation channel activity; voltage-gated potassium channel activity. There is experimental evidence that it is involved in the biological process: perineurial glial growth; potassium ion transport; flight behavior; learning; protein oligomerization. 23 alleles are reported. The phenotypes of these alleles are annotated with: leg; neuromuscular junction; synapse; adult brain. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Cyclic nucleotide-binding domain; Cyclic nucleotide-binding-like; Ion transport domain; PAC motif; PAS domain; PAS-associated, C-terminal; Potassium channel, voltage-dependent, EAG; Potassium channel, voltage-dependent, EAG/ELK/ERG; RmlC-like jelly roll fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages, during early pupal stages.

Gene summary for CG10952 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10952:CG10952 is perturbed in following parameters in primary screen: NuSize
CG10952 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10952.
Cell Count:
CG10952Primary screen503529646
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10952:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10952 is not tested in classification assay
Integrated Annotations for CG10952 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
flight behaviorGO:0007629inferred from mutant phenotype
potassium ion transport
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
voltage-gated potassium channel complexGO:0008076inferred from sequence or structural similarity with EMBL:Z34264; protein_id:CAA84018
integral to plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
voltage-gated potassium channel activityGO:0005249traceable author statement
voltage-gated cation channel activity
Other annotations
FlyBaseClick here to see CG10952 in FlyBase
FLIGHTClick here to see CG10952 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10952 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10952
Entrez GeneEntrez Gene page for CG10952
UniprotUniprot page for CG10952

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)