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Gene Page - CG Number : CG10961
Gene Summary - CG10961:

CG10961: The gene TNF-receptor-associated factor 6 is referred to in FlyBase by the symbol Dmel\Traf6 (CG10961, FBgn0026318). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: innate immune response; stress-activated protein kinase signaling cascade; regulation of I-kappaB kinase/NF-kappaB cascade; cell death. 17 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: MATH; Seven In Absentia Homolog-type; TRAF-like; TRAF-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG10961 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10961:CG10961 is perturbed in following parameters in primary screen: NuCirc NuSize
CG10961 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10961.
Cell Count:
CG_NumberCategoryR1R2R3
CG10961Primary screen9829785
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10961:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201159-0.072278715-1.206414294-0.477706206-1.322324064-4.929341847-11.67804521-8.172802403-8.516142078-10.66114738-0.127511763-2.2019941211.495709244-2.377700767-0.917368330.839362168-4.301295758-0.023041486-1.6777838660.297549727-12.329035922.080462205-1.070427702-1.212728239
2021270.638408123-0.45552022-0.1930819430.0162000862.5221469561.3466909551.0065234381.6939449131.117720710.7333484970.1406425540.1303238971.3100471281.2552468462.4254375862.382068917-0.9026363060.439791545-1.1364217560.6486183592.266177099.0115131164.085490893
2032770.209901236-0.457596769-0.006788450.3215421541.1818452951.3197813690.8239825171.5957981693.2534865570.2420917822.789534517-0.3450351171.0489584591.2552662961.4472275180.6851524731.4946949874.0446591381.175183032.9313151412.0919751178.4089330935.710475562
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10961 is not tested in classification assay
Integrated Annotations for CG10961 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dorsal closureGO:0007391traceable author statement
defense response
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
intracellularGO:0005622traceable author statement
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein bindingGO:0005515inferred from physical interaction with ECSIT
zinc ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10961 in FlyBase
FLIGHTClick here to see CG10961 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10961 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10961
Entrez GeneEntrez Gene page for CG10961
UniprotUniprot page for CG10961

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)