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Gene Page - CG Number : CG10971
Gene Summary - CG10971:

CG10971: The gene Huntingtin interacting protein 1 is referred to in FlyBase by the symbol Dmel\Hip1 (CG10971, FBgn0036309). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. Based on sequence similarity, it is predicted to be involved in the biological process: cytoskeleton organization. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ANTH; ENTH/VHS; Epsin-like, N-terminal; I/LWEQ. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG10971 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10971:CG10971 is perturbed in following parameters in primary screen: NuCirc NuSize
CG10971 is not tested in classification assay (fluid).
CG10971 is perturbed in following parameters in classification assay (transferrin): Fint1+ Tint1+
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10971.
Cell Count:
CG_NumberCategoryR1R2R3
CG10971Primary screen656916676
CG10971Secondary assay2268781108
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10971:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2011660.338625223-0.70063931-0.9323112490.35182113-0.2342513520.024017351-0.5238884350.415508403-0.305143975-0.2018507020.1463870680.4530654380.566519066-0.1985762860.1741027250.534177527-0.1205110470.14416652-0.0858529280.514892212-0.5408939891.335612669-0.315666376
202150-0.101449002-0.0193977570.8320734050.2333726671.9428896843.6434891192.4240116873.1658082483.222095657-0.261322160.0570651240.254557370.9845712941.3017415664.0072936742.1187301010.4951651411.1354439140.6517457582.9550739351.93336534610.176234593.657678908
2033000.037377681-0.1253150340.0147419760.027495090.9599448091.1459857810.1433911721.3890037531.696806247-0.1853027590.560571905-0.4618654550.3552487610.568696666-0.4135999420.5880566011.1340788870.3164172280.3992776931.5338918771.3526628657.9860926014.62706062
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG10971Slide15F0.0501.3671.4221.497
CG10971Slide15O0.2891.1871.1931.283
CG10971Slide15T0.3800.8150.4220.523
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG10971 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
cytoskeleton organizationGO:0007010inferred from sequence or structural similarity with EMBL:AJ009556
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
actin bindingGO:0003779inferred from sequence or structural similarity
phospholipid binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG10971 in FlyBase
FLIGHTClick here to see CG10971 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10971 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10971
Entrez GeneEntrez Gene page for CG10971
UniprotUniprot page for CG10971

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)