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Gene Page - CG Number : CG10975
Gene Summary - CG10975:

CG10975: The gene Protein tyrosine phosphatase 69D is referred to in FlyBase by the symbol Dmel\Ptp69D (CG10975, FBgn0014007). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process: motor neuron axon guidance; protein dephosphorylation; axon guidance; lateral inhibition; dendrite morphogenesis; defasciculation of motor neuron axon; axonogenesis. 62 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; organ system subdivision; embryonic/larval neuron; multicellular structure; peripheral nervous system; adult segment; cell part; cell projection; neuron projection; axon. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Protein-tyrosine phosphatase, active site; Protein-tyrosine phosphatase, receptor/non-receptor type; Protein-tyrosine/Dual-specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages.

Gene summary for CG10975 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10975:CG10975 is not perturbed in primary screen.
CG10975 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10975.
Cell Count:
CG_NumberCategoryR1R2R3
CG10975Primary screen538419669
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10975:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2011670.014778814-0.032057677-0.000661871-0.347170431-1.081858052-6.608471101-0.875504501-4.125167227-3.1531669120.603080329-0.283880988-0.063525725-0.901872154-0.2182619310.1676405510.041749108-0.276320819-0.2172128620.355471302-3.783898036-0.524227412-0.507849332-0.08730168
2021490.361010131-0.0805735280.1569690870.3687952130.017569235-0.448815402-0.227424686-0.260087914-1.625865166-0.755847398-0.389992422-0.856884637-1.614414912-0.503206859-0.207601070.706480612-1.507899533-0.947226531-0.98732111-1.5920259961.8911761970.9307557570.081697629
2032990.0766587320.5873939081.10425672-0.0318117250.9204476221.2249281160.6259018271.52899031.7754966270.2870049890.257725402-0.4950661060.5635699961.7089838380.885367210.521182626-0.1994511340.4460199140.5422898991.555825354-0.079625896.5427786223.538512956
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10975 is not tested in classification assay
Integrated Annotations for CG10975 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein dephosphorylationGO:0006470inferred from direct assay
defasciculation of motor neuron axon
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from sequence or structural similarity
plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein tyrosine phosphatase activityGO:0004725inferred from direct assay
transmembrane receptor protein tyrosine phosphatase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10975 in FlyBase
FLIGHTClick here to see CG10975 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10975 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10975
Entrez GeneEntrez Gene page for CG10975
UniprotUniprot page for CG10975

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)