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Gene Page - CG Number : CG1098
Gene Summary - CG1098:

CG1098: The gene MLF1-adaptor molecule is referred to in FlyBase by the symbol Dmel\Madm (CG1098, FBgn0027497). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: regulation of cell proliferation; protein secretion; regulation of cell size. 16 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG1098 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1098:CG1098 is not perturbed in primary screen.
CG1098 is perturbed in following parameters in classification assay (fluid): LP_Fclc- NuCellD+(fld) NuSize-(fld) Okt+(fld) Rto2+ Rto3+ SP_Fint1+ SP_Fint2+ SP_Fint3+
CG1098 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1098.
Cell Count:
CG_NumberCategoryR1R2R3
CG1098Primary screen68774447
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1098:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1098Slide8C0.3031.2081.0111.059
CG1098Slide8O0.0201.0451.0491.083
CG1098Slide8P0.0881.4111.1291.182
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG1098 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of cell proliferationGO:0042127inferred from direct assay
regulation of cell size
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Golgi apparatusGO:0005794inferred from direct assay
cytosol
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein serine/threonine kinase activityGO:0004674inferred from sequence or structural similarity with EMBL:AF080436
ATP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG1098 in FlyBase
FLIGHTClick here to see CG1098 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1098 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1098
Entrez GeneEntrez Gene page for CG1098
UniprotUniprot page for CG1098

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)