Gene Page - CG Number : CG10981

Gene Summary - CG10981:

CG10981: The gene degringolade is referred to in FlyBase by the symbol Dmel\dgrn (CG10981, FBgn0037384). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II repressing transcription factor binding; ubiquitin-protein ligase activity; SUMO binding. There is experimental evidence that it is involved in the biological process: regulation of establishment of protein localization; regulation of protein binding; embryo development; positive regulation of transcription, DNA-dependent; protein ubiquitination; neurogenesis; sex determination. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG10981 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG10981:

CG10981 is perturbed in following parameters in primary screen: NuSize
CG10981 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG10981.

Cell Count:

CG_Number	Category	R1	R2	R3
CG10981	Primary screen	913	521	700

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG10981:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
20	1	169	-0.078122575	-0.609238922	-0.692193984	0.721141779	0.784639554	0.79766953	-0.144708832	-0.201093137	1.083634861	-0.379839084	-0.011445585	0.067245456	-0.03285708	0.890551152	2.250797293	1.054698223	-0.200086494	-0.232505077	-0.881825705	0.70266763	2.48922131	3.967913172	2.728237743
20	2	147	-0.252396212	-0.292930029	-0.062082891	-0.010731451	1.147235581	0.946151967	0.287641352	1.022243758	1.138446636	1.350468837	-0.815719876	-0.36915493	0.566864088	0.148724207	-0.435346689	0.336866765	-0.414531528	-0.258138451	-0.576896488	0.852229957	0.429389397	3.92260449	2.394780911
20	3	297	-0.234054345	-0.594670649	-0.183092952	-0.330352086	0.073634607	2.699544143	1.665175776	2.600103154	2.264858903	-0.094111925	-0.275552069	-0.427778116	-0.508229011	-0.492951462	-0.216515555	0.937127873	-0.384818757	-1.104710359	-0.694072557	2.778709347	0.202045068	7.594516066	4.504353503

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG10981 is not tested in classification assay

Integrated Annotations for CG10981 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
sex determination	GO:0007530	inferred from mutant phenotype neurogenesis

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
nucleus	GO:0005634	inferred from direct assay cytoplasm

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
SUMO binding	GO:0032183	inferred from physical interaction with smt3 ubiquitin-protein ligase activity

Other annotations

Database	Link
FlyBase	Click here to see CG10981 in FlyBase
FLIGHT	Click here to see CG10981 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG10981 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG10981
Entrez Gene	Entrez Gene page for CG10981
Uniprot	Uniprot page for CG10981

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)