.:: RNAiDB - Gene Page ::. Gene Page - CG Number : CG10981Gene Summary - CG10981:CG10981: The gene degringolade is referred to in FlyBase by the symbol Dmel\dgrn (CG10981, FBgn0037384). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II repressing transcription factor binding; ubiquitin-protein ligase activity; SUMO binding. There is experimental evidence that it is involved in the biological process: regulation of establishment of protein localization; regulation of protein binding; embryo development; positive regulation of transcription, DNA-dependent; protein ubiquitination; neurogenesis; sex determination. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Gene summary for CG10981 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)Experimental Summary - CG10981:CG10981 is perturbed in following parameters in primary screen: NuSize CG10981 is not tested in classification assay. Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10981.Cell Count:CG_NumberCategoryR1R2R3CG10981Primary screen913521700R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3Primary screen data - CG10981: SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize201169-0.078122575-0.609238922-0.6921939840.7211417790.7846395540.79766953-0.144708832-0.2010931371.083634861-0.379839084-0.0114455850.067245456-0.032857080.8905511522.2507972931.054698223-0.200086494-0.232505077-0.8818257050.702667632.489221313.9679131722.728237743202147-0.252396212-0.292930029-0.062082891-0.0107314511.1472355810.9461519670.2876413521.0222437581.1384466361.350468837-0.815719876-0.369154930.5668640880.148724207-0.4353466890.336866765-0.414531528-0.258138451-0.5768964880.8522299570.4293893973.922604492.394780911203297-0.234054345-0.594670649-0.183092952-0.3303520860.0736346072.6995441431.6651757762.6001031542.264858903-0.094111925-0.275552069-0.427778116-0.508229011-0.492951462-0.2165155550.937127873-0.384818757-1.104710359-0.6940725572.7787093470.2020450687.5945160664.504353503 SN: Slide Number; RN: Replicate Number; WN: Well NumberExperimental Data (Classification Assay):CG10981 is not tested in classification assayIntegrated Annotations for CG10981 :Gene Ontology Annoations: Biological ProcessBiological Process - TermGO IDEvidencesex determinationGO:0007530inferred from mutant phenotype neurogenesisGene Ontology Annoations: Cellular ComponentCellular Component - TermGO IDEvidencenucleusGO:0005634inferred from direct assay cytoplasmGene Ontology Annoations: Molecular FunctionMolecular Function - TermGO IDEvidenceSUMO bindingGO:0032183inferred from physical interaction with smt3 ubiquitin-protein ligase activity Other annotations DatabaseLinkFlyBaseClick here to see CG10981 in FlyBaseFLIGHTClick here to see CG10981 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)BioGRIDClick here to see CG10981 in BioGRID (Interaction Summary)Off-targetClick here for Off-target data for CG10981Entrez GeneEntrez Gene page for CG10981UniprotUniprot page for CG10981 Endosite Team : Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in) Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)
.:: RNAiDB - Gene Page ::. Gene Page - CG Number : CG10981Gene Summary - CG10981:CG10981: The gene degringolade is referred to in FlyBase by the symbol Dmel\dgrn (CG10981, FBgn0037384). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II repressing transcription factor binding; ubiquitin-protein ligase activity; SUMO binding. There is experimental evidence that it is involved in the biological process: regulation of establishment of protein localization; regulation of protein binding; embryo development; positive regulation of transcription, DNA-dependent; protein ubiquitination; neurogenesis; sex determination. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Gene summary for CG10981 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)Experimental Summary - CG10981:CG10981 is perturbed in following parameters in primary screen: NuSize CG10981 is not tested in classification assay. Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10981.Cell Count:CG_NumberCategoryR1R2R3CG10981Primary screen913521700R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3Primary screen data - CG10981: SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize201169-0.078122575-0.609238922-0.6921939840.7211417790.7846395540.79766953-0.144708832-0.2010931371.083634861-0.379839084-0.0114455850.067245456-0.032857080.8905511522.2507972931.054698223-0.200086494-0.232505077-0.8818257050.702667632.489221313.9679131722.728237743202147-0.252396212-0.292930029-0.062082891-0.0107314511.1472355810.9461519670.2876413521.0222437581.1384466361.350468837-0.815719876-0.369154930.5668640880.148724207-0.4353466890.336866765-0.414531528-0.258138451-0.5768964880.8522299570.4293893973.922604492.394780911203297-0.234054345-0.594670649-0.183092952-0.3303520860.0736346072.6995441431.6651757762.6001031542.264858903-0.094111925-0.275552069-0.427778116-0.508229011-0.492951462-0.2165155550.937127873-0.384818757-1.104710359-0.6940725572.7787093470.2020450687.5945160664.504353503 SN: Slide Number; RN: Replicate Number; WN: Well NumberExperimental Data (Classification Assay):CG10981 is not tested in classification assayIntegrated Annotations for CG10981 :Gene Ontology Annoations: Biological ProcessBiological Process - TermGO IDEvidencesex determinationGO:0007530inferred from mutant phenotype neurogenesisGene Ontology Annoations: Cellular ComponentCellular Component - TermGO IDEvidencenucleusGO:0005634inferred from direct assay cytoplasmGene Ontology Annoations: Molecular FunctionMolecular Function - TermGO IDEvidenceSUMO bindingGO:0032183inferred from physical interaction with smt3 ubiquitin-protein ligase activity Other annotations DatabaseLinkFlyBaseClick here to see CG10981 in FlyBaseFLIGHTClick here to see CG10981 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)BioGRIDClick here to see CG10981 in BioGRID (Interaction Summary)Off-targetClick here for Off-target data for CG10981Entrez GeneEntrez Gene page for CG10981UniprotUniprot page for CG10981
CG10981: The gene degringolade is referred to in FlyBase by the symbol Dmel\dgrn (CG10981, FBgn0037384). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II repressing transcription factor binding; ubiquitin-protein ligase activity; SUMO binding. There is experimental evidence that it is involved in the biological process: regulation of establishment of protein localization; regulation of protein binding; embryo development; positive regulation of transcription, DNA-dependent; protein ubiquitination; neurogenesis; sex determination. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
Endosite Team : Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in) Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)