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Gene Page - CG Number : CG10981
Gene Summary - CG10981:

CG10981: The gene degringolade is referred to in FlyBase by the symbol Dmel\dgrn (CG10981, FBgn0037384). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II repressing transcription factor binding; ubiquitin-protein ligase activity; SUMO binding. There is experimental evidence that it is involved in the biological process: regulation of establishment of protein localization; regulation of protein binding; embryo development; positive regulation of transcription, DNA-dependent; protein ubiquitination; neurogenesis; sex determination. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG10981 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10981:CG10981 is perturbed in following parameters in primary screen: NuSize
CG10981 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10981.
Cell Count:
CG_NumberCategoryR1R2R3
CG10981Primary screen913521700
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10981:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201169-0.078122575-0.609238922-0.6921939840.7211417790.7846395540.79766953-0.144708832-0.2010931371.083634861-0.379839084-0.0114455850.067245456-0.032857080.8905511522.2507972931.054698223-0.200086494-0.232505077-0.8818257050.702667632.489221313.9679131722.728237743
202147-0.252396212-0.292930029-0.062082891-0.0107314511.1472355810.9461519670.2876413521.0222437581.1384466361.350468837-0.815719876-0.369154930.5668640880.148724207-0.4353466890.336866765-0.414531528-0.258138451-0.5768964880.8522299570.4293893973.922604492.394780911
203297-0.234054345-0.594670649-0.183092952-0.3303520860.0736346072.6995441431.6651757762.6001031542.264858903-0.094111925-0.275552069-0.427778116-0.508229011-0.492951462-0.2165155550.937127873-0.384818757-1.104710359-0.6940725572.7787093470.2020450687.5945160664.504353503
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10981 is not tested in classification assay
Integrated Annotations for CG10981 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
sex determinationGO:0007530inferred from mutant phenotype
neurogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from direct assay
cytoplasm
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
SUMO bindingGO:0032183inferred from physical interaction with smt3
ubiquitin-protein ligase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10981 in FlyBase
FLIGHTClick here to see CG10981 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10981 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10981
Entrez GeneEntrez Gene page for CG10981
UniprotUniprot page for CG10981

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)