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Gene Page - CG Number : CG1099
Gene Summary - CG1099:

CG1099: The gene Dynamin associated protein 160 is referred to in FlyBase by the symbol Dmel\Dap160 (CG1099, FBgn0023388). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; protein localization; positive regulation of protein kinase activity; positive regulation of neuroblast proliferation; synaptic vesicle endocytosis; synaptic growth at neuromuscular junction. 25 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; bouton; neuromuscular junction; eo sensory structure; embryonic/larval neuromuscular junction; synaptic vesicle; embryonic/larval neuroblast. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand-like domain; EPS15 homology (EH); Neutrophil cytosol factor 2 p67phox; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG1099 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1099:CG1099 is not perturbed in primary screen.
CG1099 is not tested in classification assay (fluid).
CG1099 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fclc- Fint4- Fmph1- Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tclc- Tint2-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1099.
Cell Count:
CG_NumberCategoryR1R2R3
CG1099Primary screen174879280
CG1099Secondary assay142748702
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1099:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1099Slide15F0.7531.2700.8880.981
CG1099Slide15O0.1881.1141.0141.218
CG1099Slide15T0.0960.5900.9230.691
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1099 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein localizationGO:0008104inferred from mutant phenotype
synaptic growth at neuromuscular junction
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
presynaptic membraneGO:0042734colocalizes_with inferred from direct assay
cytoplasm
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein bindingGO:0005515inferred from physical interaction with aPKC inferred from physical interaction with par-6
calcium ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG1099 in FlyBase
FLIGHTClick here to see CG1099 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1099 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1099
Entrez GeneEntrez Gene page for CG1099
UniprotUniprot page for CG1099

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)