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Gene Page - CG Number : CG10992
Gene Summary - CG10992:

CG10992: The gene Cathepsin B1 is referred to in FlyBase by the symbol Dmel\CtsB1 (CG10992, FBgn0030521). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cysteine peptidase, asparagine active site; Cysteine peptidase, cysteine active site; Cysteine peptidase, histidine active site; Peptidase C1A, cathepsin B; Peptidase C1A, papain; Peptidase C1A, papain C-terminal; Peptidase C1A, propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG10992 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10992:CG10992 is perturbed in following parameters in primary screen: NuCirc NuFluct NuSize
CG10992 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10992.
Cell Count:
CG_NumberCategoryR1R2R3
CG10992Primary screen941487909
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10992:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2011753.5353137450.2096110840.553967258-0.4928878650.6334403372.3311153691.8844066412.1092532732.7672798550.9543162070.072563693-0.12505867-0.0535105521.2495820031.7228298430.9545002190.0845111961.0059178831.7378917042.8828788441.4823836657.3923518919.591245036
2021410.074810734-0.474932656-0.616825846-0.1167601030.8992923270.782327154-0.117744181.010474610.1932141790.1410045690.3340707770.8528890160.452376530.0583102120.1503217670.394817771-0.3203826730.1437289052.412650481-0.2038637750.7234280680.12778647-0.321471337
2032910.7449020950.3138520040.7360252590.8992333151.8326934222.642595091.2612519342.696815634.1045257280.1292120253.7347239120.2324276810.6862449751.9075233390.3979032890.5964012951.8974809034.025887081.2264173744.001857905-0.45942568110.641335549.75971346
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10992 is not tested in classification assay
Integrated Annotations for CG10992 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
autophagic cell deathGO:0048102inferred from expression pattern
salivary gland cell autophagic cell death
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
cysteine-type endopeptidase activityGO:0004197inferred from sequence or structural similarity with UniProtKB:P07858
Other annotations
DatabaseLink
FlyBaseClick here to see CG10992 in FlyBase
FLIGHTClick here to see CG10992 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10992 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10992
Entrez GeneEntrez Gene page for CG10992
UniprotUniprot page for CG10992

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)