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Gene Page - CG Number : CG10997
Gene Summary - CG10997:

CG10997: The gene Chloride intracellular channel is referred to in FlyBase by the symbol Dmel\Clic (CG10997, FBgn0030529). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: calcium ion binding; chloride channel activity; lipid binding. There is experimental evidence that it is involved in the biological process: chloride transport; response to alcohol; determination of adult lifespan; response to oxidative stress; negative gravitaxis. 20 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Glutathione S-transferase, C-terminal-like; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.

Gene summary for CG10997 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG10997:CG10997 is perturbed in following parameters in primary screen: NuCirc NuSize
CG10997 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG10997.
Cell Count:
CG_NumberCategoryR1R2R3
CG10997Primary screen1045512884
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG10997:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201178-0.0533837030.9073299351.006160208-0.6379970351.1263508062.6836726222.5072865452.3965437113.515617881.017537402-0.1648128582.1289656651.9297535351.6715669380.3736544431.162195855-0.634908224-0.525057172-0.3666977723.0388275971.5771101757.5392690058.526504777
202138-0.111890921-0.1191363830.9668697322.4000587270.6182304111.3137986131.9455772351.4251228610.882376327-0.3453568420.3278658131.260470154-1.152244123-0.6250422472.5911201920.729912867-2.124428724-0.057046373-0.2484359441.156660782-0.4767681712.067097217-0.427607587
203288-0.4338141020.08761822-0.0594415970.2938405181.4031730932.4605319291.1505155482.7378907822.798614203-0.1614104660.5900034780.104153487-0.328372883-0.1089361561.496680711.4876636790.237067990.206146133-0.1655289012.9964049880.0928177356.4175721194.069190394
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG10997 is not tested in classification assay
Integrated Annotations for CG10997 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
determination of adult lifespanGO:0008340inferred from mutant phenotype
response to oxidative stress
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
chloride channel activityGO:0005254inferred from sequence or structural similarity with NCBI_gi:4557020
chloride channel activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG10997 in FlyBase
FLIGHTClick here to see CG10997 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG10997 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG10997
Entrez GeneEntrez Gene page for CG10997
UniprotUniprot page for CG10997

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)