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Gene Page - CG Number : CG1100
Gene Summary - CG1100:

CG1100: The gene Regulatory particle non-ATPase 5 is referred to in FlyBase by the symbol Dmel\Rpn5 (CG1100, FBgn0028690). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: proteolysis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Proteasome component (PCI) domain; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.

Gene summary for CG1100 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1100:CG1100 is perturbed in following parameters in primary screen: Fclc Fint1 Fint2 Fint3 Fmph1 Fmph2 Fmph3 Tclc Tint2 Tmph1 Tmph2 Tmph3
CG1100 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fmph1- LP_Fmph3- LP_Fnum- NuSize-(fld) Rto2- Rto3- SP_Fclc- SP_Fint1- SP_Fint2- SP_Fint3-
CG1100 is perturbed in following parameters in classification assay (transferrin): Fclc- Fint1- Fint2- Fint3- Fint4- Fmph1- Fmph2- Fmph3- Fnum- Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tclc- Tint1- Tint2- Tint3- Tmph1- Tmph2- Tmph3-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1100.
Cell Count:
CG_NumberCategoryR1R2R3
CG1100Primary screen175738231
CG1100Secondary assay588349880
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1100:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1100Slide10C0.1430.6810.7570.975
CG1100Slide10O0.7060.9221.1030.881
CG1100Slide10P0.0020.4260.5250.594
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1100Slide2F0.0000.4830.5130.564
CG1100Slide2O0.1080.9470.6910.676
CG1100Slide2T0.0000.4830.3840.320
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1100 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508inferred from direct assay AND inferred from sequence or structural similarity with HGNC_gene:PSMD12; HGNC:9557; OMIM:604450 AND inferred from sequence or structural similarity with SGD_LOCUS:RPN5; SGD:S0002306
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
proteasome regulatory particle, lid subcomplexGO:0008541non-traceable author statement
proteasome regulatory particle
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
endopeptidase activityGO:0004175inferred from direct assay
Other annotations
DatabaseLink
FlyBaseClick here to see CG1100 in FlyBase
FLIGHTClick here to see CG1100 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1100 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1100
Entrez GeneEntrez Gene page for CG1100
UniprotUniprot page for CG1100

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)