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Gene Page - CG Number : CG11033
Gene Summary - CG11033:

CG11033: The gene Lysine (K)-specific demethylase 2 is referred to in FlyBase by the symbol Dmel\Kdm2 (CG11033, FBgn0037659). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone demethylase activity (H3-trimethyl-K4 specific). There is experimental evidence that it is involved in the biological process: segment specification; histone H3-K36 demethylation; histone H3-K4 demethylation, trimethyl-H3-K4-specific; histone H2A ubiquitination. 34 alleles are reported. The phenotype of these alleles is annotated with: nucleolus. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: F-box domain, cyclin-like; JmjC domain; Leucine-rich repeat, cysteine-containing subtype; Zinc finger, CXXC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.

Gene summary for CG11033 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11033:CG11033 is not perturbed in primary screen.
CG11033 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11033.
Cell Count:
CG_NumberCategoryR1R2R3
CG11033Primary screen747760767
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11033:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201197-0.4562880720.024291556-0.433518582-0.064177790.3993363950.802963862-0.0418536060.886755963-0.0465002411.9805479951.496748384-0.1687257950.0547247050.0933271610.934790171.223742250.3650786140.8904209620.8145279180.8943294931.2419225910.5213430430.503829469
2021190.303123274-0.452959176-0.390336045-0.7129726570.88451592.0163060551.6458052542.1158438542.1766364421.9979590850.5191975490.2471989210.5205479730.00311773.7959220360.652168430.8584123761.297547780.6890167082.0617393350.3284508312.9830803931.118265358
203269-0.495059831-0.497010965-0.161069263-0.6330098550.921169542.2052651221.0661368562.3424389652.826938202-0.019637268-0.2374701190.1360425740.182679530.6214242570.2092626511.5217670721.5321026921.0688552941.822109622.749220950.2277590336.6389767694.915543379
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11033 is not tested in classification assay
Integrated Annotations for CG11033 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
histone H3-K4 demethylation, trimethyl-H3-K4-specificGO:0034721inferred from mutant phenotype
segment specification
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
PcG protein complexGO:0031519inferred from physical interaction with Sce, Psc
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
histone demethylase activity (H3-trimethyl-K4 specific)GO:0034647inferred from mutant phenotype
DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11033 in FlyBase
FLIGHTClick here to see CG11033 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11033 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11033
Entrez GeneEntrez Gene page for CG11033
UniprotUniprot page for CG11033

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)