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Gene Page - CG Number : CG1106
Gene Summary - CG1106:

CG1106: The gene Gelsolin is referred to in FlyBase by the symbol Dmel\Gel (CG1106, FBgn0010225). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 7 alleles are reported. The phenotypes of these alleles are annotated with: mitochondrion; adult brain. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Gelsolin; Gelsolin domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout the larval period, during early pupal stages.

Gene summary for CG1106 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1106:CG1106 is perturbed in following parameters in primary screen: Fclc Fmph1 Fmph3 NuCirc Okt Tclc
CG1106 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint1+ LP_Fint4- NuSize-(fld) Okt-(fld) Rto1- SP_Fint4-
CG1106 is perturbed in following parameters in classification assay (transferrin): Fclc- Fint1- Fint2- Fint3- Fint4- NuCellD+(tfr) Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint1- Tint2- Tint3- Tmph1-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1106.
Cell Count:
CG_NumberCategoryR1R2R3
CG1106Primary screen730747948
CG1106Secondary assay804972979
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1106:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1106Slide10C0.2381.1381.3111.005
CG1106Slide10O0.0010.7380.6260.677
CG1106Slide10P0.7380.9850.9970.939
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1106Slide2F0.0150.8930.8470.779
CG1106Slide2O0.3000.9730.9890.916
CG1106Slide2T0.0890.8000.8110.466
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1106 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
phagocytosis, engulfmentGO:0006911inferred from mutant phenotype
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
actin filamentGO:0005884inferred from direct assay
cytosol
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
actin bindingGO:0003779inferred from sequence or structural similarity
actin binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG1106 in FlyBase
FLIGHTClick here to see CG1106 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1106 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1106
Entrez GeneEntrez Gene page for CG1106
UniprotUniprot page for CG1106

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)