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Gene Page - CG Number : CG1107
Gene Summary - CG1107:

CG1107: The gene auxillin is referred to in FlyBase by the symbol Dmel\aux (CG1107, FBgn0037218). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: sperm individualization; Notch signaling pathway; compound eye morphogenesis. 56 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; organ system subdivision; adult segment; external compound sense organ; adult; thoracic segment; peripheral nervous system; portion of tissue; histaminergic neuron; cystic bulge. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: C2 calcium/lipid-binding domain, CaLB; Heat shock protein DnaJ, N-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Tensin phosphatase, C2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG1107 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1107:CG1107 is perturbed in following parameters in primary screen: Fint2 Fint3 Fmph2 Tclc
CG1107 is perturbed in following parameters in classification assay (fluid): LP_Fint2- LP_Fint3- LP_Fmph1- LP_Fmph2- LP_Fmph3- LP_Fnum- SP_Fint3-
CG1107 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1107.
Cell Count:
CG_NumberCategoryR1R2R3
CG1107Primary screen444472561
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1107:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1107Slide8C0.0020.7250.6890.791
CG1107Slide8O0.1931.2251.0441.057
CG1107Slide8P0.0610.9380.8090.875
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG1107 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein phosphorylationGO:0006468non-traceable author statement
synaptic vesicle uncoating
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Golgi stackGO:0005795inferred from direct assay
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein kinase activityGO:0004672non-traceable author statement
ATP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG1107 in FlyBase
FLIGHTClick here to see CG1107 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1107 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1107
Entrez GeneEntrez Gene page for CG1107
UniprotUniprot page for CG1107

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)