Gene Page - CG Number : CG11093

Gene Summary - CG11093:

CG11093: The gene fussel is referred to in FlyBase by the symbol Dmel\fuss (CG11093, FBgn0039932). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: co-SMAD binding. There is experimental evidence that it is involved in the biological process: negative regulation of BMP signaling pathway; imaginal disc-derived wing vein specification. 11 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; mushroom body; sensillum campaniformium of dorsal radius; posterior crossvein; wing; mushroom body gamma neuron; mushroom body vertical lobe; mushroom body alpha/beta neuron; wing vein; wing vein L2. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: DNA binding domain, putative; SAND domain-like; Transcription regulator SKI/SnoN; Transforming protein Ski; c-SKI SMAD4-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, in adult female stages.

Gene summary for CG11093 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG11093:

CG11093 is perturbed in following parameters in primary screen: NuCirc NuSize
CG11093 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG11093.

Cell Count:

CG_Number	Category	R1	R2	R3
CG11093	Primary screen	333	1235	899

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG11093:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
20	1	227	-0.639813257	0.188000264	0.376750189	-1.240751991	-1.299211252	-4.348035209	-3.262331492	-3.323197479	-0.192803396	-0.105578327	-0.432638123	-0.26620409	-0.82947769	0.19133524	1.632960164	-0.691532075	-0.407152463	0.274045179	1.900080904	-4.30741369	-0.105565084	0.06400998	-0.638151071
20	2	89	2.20414236	-0.050561963	0.399121484	0.18673735	2.637983594	2.348087334	1.52227768	2.646082449	2.871340107	0.611884446	0.352749288	0.114540155	3.760370191	2.626922301	3.260025987	2.242282174	0.098947374	0.220042213	0.148718189	2.480935916	2.796883757	10.91724602	7.024707961
20	3	239	-0.595534235	-0.386041007	-0.159434479	-0.134774991	1.18820587	2.731569569	1.411354806	2.882367706	2.76113386	-0.144047371	-0.168163714	1.211988828	-0.252513957	0.216355569	0.328779679	1.445892934	1.174818912	0.58664995	1.367385484	2.976175121	0.952561875	5.645324187	4.217984548

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG11093 is not tested in classification assay

Integrated Annotations for CG11093 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
-

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
nucleus	GO:0005634	inferred from electronic annotation with InterPro:IPR003380, InterPro:IPR010919

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
SMAD binding	GO:0046332	inferred from electronic annotation with InterPro:IPR014890 nucleotide binding

Other annotations

Database	Link
FlyBase	Click here to see CG11093 in FlyBase
FLIGHT	Click here to see CG11093 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG11093 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG11093
Entrez Gene	Entrez Gene page for CG11093
Uniprot	Uniprot page for CG11093

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)