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Gene Page - CG Number : CG11094
Gene Summary - CG11094:

CG11094: The gene doublesex is referred to in FlyBase by the symbol Dmel\dsx (CG11094, FBgn0000504). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; protein binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; protein homodimerization activity. There is experimental evidence that it is involved in the biological process: imaginal disc-derived female genitalia development; regulation of transcription from RNA polymerase II promoter; imaginal disc-derived male genitalia development; genital disc development; axon midline choice point recognition. 133 alleles are reported. The phenotypes of these alleles are annotated with 31 unique terms, many of which group under: organ system; organ system subdivision; adult segment; imaginal precursor; portion of tissue; larval abdominal segment; male accessory gland; external compound sense organ; female genitalia; integumentary specialisation; acellular anatomical structure. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: DM DNA-binding; DMRT/protein doublesex/protein male abnormal 3; Doublesex dimerisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early pupal stages, in adult male stages.

Gene summary for CG11094 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11094:CG11094 is not perturbed in primary screen.
CG11094 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11094.
Cell Count:
CG_NumberCategoryR1R2R3
CG11094Primary screen703784663
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11094:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2012280.586426004-0.5344270720.1896314910.2438618220.583946232-1.034863011-0.795951879-0.1193492520.88185567-0.5504779440.3459756550.4041433770.068124429-0.026557740.7972790471.1527781820.525271668-0.5649654220.3237557690.540013052-0.067411672-0.651931007-0.540623708
20288-0.239598738-0.1181886240.040665027-0.2604891081.5013915322.0184337951.4752521152.0406189871.9560904641.4180336930.9581483860.0575095991.0675073820.922283411-0.0573824541.453546140.8117697821.2163789990.9841295421.8569606362.0267448132.7132680611.033645147
203238-0.298333423-0.724123785-0.2290500880.0520486871.0955459661.9150073671.0006642962.1226267851.762915019-0.747053662-0.1839442140.390064492-0.0087507280.027609146-0.3219022880.2608310610.063116583-0.1867436580.7157018331.690392481-0.089823195-0.160564861-0.283446033
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11094 is not tested in classification assay
Integrated Annotations for CG11094 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
imaginal disc-derived female genitalia developmentGO:0007486inferred from genetic interaction with tra2
genital disc development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with EMBL:AF130728; protein_id:AAD40474.1
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677non-traceable author statement
zinc ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11094 in FlyBase
FLIGHTClick here to see CG11094 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11094 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11094
Entrez GeneEntrez Gene page for CG11094
UniprotUniprot page for CG11094

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)