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Gene Page - CG Number : CG11121
Gene Summary - CG11121:

CG11121: The gene sine oculis is referred to in FlyBase by the symbol Dmel\so (CG11121, FBgn0003460). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: entrainment of circadian clock; ring gland development; positive regulation of transcription from RNA polymerase II promoter; glial cell migration; circadian rhythm; optic lobe placode formation; compound eye morphogenesis; spermatogenesis; Bolwig's organ morphogenesis. 55 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: organ system subdivision; organ system; adult segment; external compound sense organ; larval head segment; adult; peripheral nervous system; extended germ band embryo; embryonic stomatogastric nervous system; embryonic/larval neuron; imaginal precursor; ectoderm derivative; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period.

Gene summary for CG11121 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11121:CG11121 is not perturbed in primary screen.
CG11121 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11121.
Cell Count:
CG_NumberCategoryR1R2R3
CG11121Primary screen365796307
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11121:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201243-0.601192188-0.516456964-0.537872110.178337965-0.878478401-1.206593263-0.914441019-0.968492298-1.5445303110.9115632340.5062212652.2133222571.1205518821.2843265813.1940167360.2486904280.0353959870.2308427640.425938941-0.842467905-0.5921695431.9607453061.585991403
20243-0.508131-0.2695626970.092778457-0.0972610671.7343032941.7096917220.7241959582.0228986251.5555503651.8964549150.667846097-0.069809451.224087451.848727822.6541976631.280866260.4541967440.9987352980.6717541691.323232532-0.0054599555.6522701521.259180802
203193-0.4296585510.089779327-0.444654410.580244069-0.280457015-1.718819472-1.68004785-2.31587064-2.733277323-0.992374973-0.017198538-0.79235532-0.606473276-1.512037213-0.371649282-0.420516486-0.128573944-1.3386227080.435425741-2.6512510370.287700625-0.0962989261.096074206
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11121 is not tested in classification assay
Integrated Annotations for CG11121 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of transcription, DNA-dependentGO:0006355inferred from sequence or structural similarity with UniProtKB:Q62231
Bolwig's organ morphogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with MGD:Six2; MGI:MGI:102778
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA bindingGO:0043565inferred from mutant phenotype
protein binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11121 in FlyBase
FLIGHTClick here to see CG11121 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11121 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11121
Entrez GeneEntrez Gene page for CG11121
UniprotUniprot page for CG11121

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)