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Gene Page - CG Number : CG11130
Gene Summary - CG11130:

CG11130: The gene Rtc1 is referred to in FlyBase by the symbol Dmel\Rtc1 (CG11130, FBgn0020909). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: RNA-3'-phosphate cyclase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: RNA processing; ribosome biogenesis. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: RNA 3'-terminal phosphate cyclase; RNA 3'-terminal phosphate cyclase domain; RNA 3'-terminal phosphate cyclase type 2; RNA 3'-terminal phosphate cyclase, insert domain; RNA 3'-terminal phosphate cyclase-like, conserved site; RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages.

Gene summary for CG11130 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11130:CG11130 is perturbed in following parameters in primary screen: NuSize
CG11130 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11130.
Cell Count:
CG_NumberCategoryR1R2R3
CG11130Primary screen354597567
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11130:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2012450.8809444220.110815983-0.450164566-0.361894405-0.933730737-1.547713805-0.561057257-1.1048226540.325120648-0.752695141.5009874070.779539974-0.817271907-0.8937207852.448271017-0.956342648-0.7623134482.361611578-0.053191854-0.34783694-0.6336375594.306966567.344216616
202411.530659022-0.58172268-0.554732668-0.607836971.0469661611.5678898770.6429535971.5056829062.6193659491.3844762752.327619662-0.1985043733.1873523463.7103274111.1422227820.3440843630.98158084.636768111.2265659222.0449707990.1346326384.3127664812.86428394
203191-0.0197910150.126084806-0.377442934-0.8623522610.6129769211.0921917910.2369848381.2736319591.389071357-0.869795421-0.6417790440.3314136810.8826743440.582520531-0.6684224680.102529257-0.666989665-1.386548893-0.4267455140.7079694740.4860163181.037267672-0.091921107
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11130 is not tested in classification assay
Integrated Annotations for CG11130 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
ribosome biogenesisGO:0042254inferred from electronic annotation with InterPro:IPR016443
RNA processing
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634non-traceable author statement
nucleolus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
RNA-3'-phosphate cyclase activityGO:0003963inferred from sequence or structural similarity with UniProtKB:Q08096
Other annotations
DatabaseLink
FlyBaseClick here to see CG11130 in FlyBase
FLIGHTClick here to see CG11130 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11130 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11130
Entrez GeneEntrez Gene page for CG11130
UniprotUniprot page for CG11130

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)